Chemical Name：alpha-cyano-4-fluoro-3-phenoxybenzyl-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate; cyfluthrin
CAS：68359-37-5

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	14 values of rat LD50 were obtained in oral administration tests (1271, 869, 1189, 590, 795, 926, 499, 505, 254, 396, 16.2, 500-1000, 155, and 160 mg/kg bw) (JECFA No. 891 (1997)) (DFGOT vol. 23 (2003)). Of these 14 values, nine values represent Category 4 (300 < LD50 <= 2000 mg/kg bw), three values represent Category 3, 1 value represents Category 2, and one value represents "Classification not possible" category. Thus, the substance was classified into Category 4, which best represents the overall results.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on its rat LD50 of > 5000 mg/kg (JECFA No. 891 (1997)), the substance was classified into "Not classified" using the JIS classification criteria (Category 5 in the United Nations classification).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Its documented rat LC50 values consists of one value equivalent to Category 4 (1.089 mg/L), one value equivalent to Category 3 (0.575 mg/L), two values equivalent to Category 2 or 3 (0.469-0.592 mg/L; 0.2-0.735 mg/L), and two values equivalent to Category 2 (0.405-0.49 mg/L) (DFGOT vol. 23 (2003)) (JECFA No. 891 (1997)). Prioritizing best represented category and more toxic values, the substance was classified into Category 2. Also, it is rated as R26/28 (equivalent to Category 1 or 2) or R23 (equivalent to Category 2) in the EU classification (EU-Annex 1 (accessed in February 2009).
2	Skin corrosion/irritation	Not classified	-	-	-	-	Since two different tests using rats found that the substance is not irritating (DFGOT vol. 23 (2003)), the substance was classified into "Not classified".
3	Serious eye damage/eye irritation	Category 2		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	Since both of two tests using rats found that the substance is a primary irritant (DFGOT vol. 23 (2003)), the substance was classified into Category 2.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Not classified	-	-	-	-	Since two different maximization tests using guinea pigs (DFGOT vol. 23 (2003)) found that the substance is not skin sensitizing, it was classified into "Not classified".
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Classification not possible due to lack of data. As additional information, negative results have been documented in dominant lethal tests using mice that underwent oral administration, and chromosomal aberration tests using bone marrow cells of mice that underwent oral administration. However, these results were not used for classification because of the notes pointing out some defects found in these experiments that made these results less reliable (JECFA No. 891 (1997)). Regarding in vitro mutagenicity tests, negative results were documented in Ames tests, mutation tests using CHO cells, chromosomal aberration tests using CHL cells, and chromosomal aberration tests using human lymphocytes (JECFA No. 891 (1997), DFGOT vol. 23 (2003)).
6	Carcinogenicity	Not classified	-	-	-	-	No increase in tumorigenesis was detected in two-year oral administration tests using rats, and 23- and 18-month oral administration tests using mice (DFGOT vol. 23 (2003)). Thus, the substance was classified into "Not classified".
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In developmental toxicity tests using rabbits that underwent oral administration (OECD TG 414-compliant) (JECFA No. 891 (1997), HSDB (2008)), embryo resorption occurred at the doses (60 and 180 mg/kg bw /day) that are known to suppress body weight gain in maternal animals. Thus, the substance was classified into Category 2.
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)		Danger	H370: Causes damage to organs (nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	In rats that underwent inhalation exposure to 0.405 mg/L/4h (OECD TG 403), continued choreoathetoid movement, cyanosis, irregular respiration accompanied with labored breathing, abnormal phonation, or prone or side position with eyes closed were observed (DFGOT vol. 23 (2007)). Based on these observations, the substance was classified into Category 1 (nervous system). In rodents (rats and mice) that underwent oral exposure, it has been documented that the LD50 values were 291 to 1271 mg/kg, and treated animals showed signs of choreoathetosis, restlessness, salivation, lowered motor functions, ataxia, gait disorder, decreased breathing rate, labored breathing and apathy (DFGOT vol. 23 (2007)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (nervous system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In 4-week forced oral administration tests using rats, symptoms such as apathy, ataxia, ruffled coat and dyspnoea were observed at 80 mg/kg bw /day (90-day conversion value: 27 mg/kg bw /day, which falls under Category 2). In 1-month oral administration (mixed diet) tests, straddled gait, salivation, nervousness and degeneration of sciatic nerve were observed and these symptoms disappeared when administration was terminated (JECFA No. 891 (1997)). In 3-month oral administration tests using mixed diet, degeneration of sciatic nerve was observed in 5 male and 3 female rats out of 20 rats in 1000 mg/kg-administration groups (11 mg/kg/day, which falls under Category 2 dose range); 1 of 8 affected rats recovered after the end of administration (JECA No. 891 (1997)); and temporal dysbasia and body weight loss were detected (DFGOT vol. 23 (2007)) in 500 mg/kg-administration groups (male dose: 38.9 mg/kg bw /day, and female dose: 42.9 mg/kg bw /day, which fall under Category 2 dose range). Among inhalation tests using rats, in 3-week tests, ungroomed coat, abnormal gait, salivation and a decreased body weight gain during the administration period were observed at 250 microg/L (90-day conversion value: 0.06 mg/L) (JMPR "Summary of toxicological evaluations" (2006) and No. 763 (1987)); in 13-week tests, "non-specific behavioral disturbances" at 20 microg/L (= 0.02 mg/L, which falls under Category 1 dose range) and decreased weight of various organs at 3.0 and 20 microg/L (= 0.003 mg/L and 0.02 mg/L, respectively, which fall under Category 1 dose range) were observed (JMPR "Summary of toxicological evaluations" (2006) and No. 763 (1987)); in 4-week tests, body weight loss in male rats, temporal hyporeflexia or bradykinesia, hypothermia, decreased leukocytes and the thymus weight, and increased uric acid concentration were detected at 6.0 mg/m3 (90-day conversion value: 0.002 mg/L, which falls under Category 1 dose range), and piloerection, and abnormal activities and bradykinesia were recorded after exposure to 46.6 mg/m3 (90-day conversion value: 0.016 mg/L, which falls under Category 1 dose range) (DFGOT vol. 23 (2007)). However, under microscopic examinations, administration of the substance did not show any damage (JMPR "Summary of toxicological evaluations" (2006) and No. 763 (1987)), and there are no cases of histopathological observations (DFGOT vol. 23 (2007)). Based on these results, the substance was classified into Category 1 (nervous system) since the effects of the substance were detected at Category 1 guidance doses.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since its 48-hour EC50 = 0.000025 mg/L for crustaceans (Daphnia magna) (AQUIRE, 2008), the substance was classified into Category 1.
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Its classification for acute toxicity is Category 1 and it is not rapidly degradable (BIOWIN), the substance was classified into Category 1.