Chemical Name：Creosote oil; [A complex combination of hydrocarbons obtained by the distillation of coal tar. It consists primarily of aromatic hydrocarbons and may contain appreciable quantities of tar acids and tar bases. It distills at the approximate range of 200degC
CAS：61789-28-4

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on its rat LD50 of 2524 mg/kg(complied with OECD TG 401; CICAD 62 (2004)), the substance was classified into "Not classified" using the JIS classification criteria (Category 5 in the United Nations classification). Regarding toxicity of creosote oil (CAS No. 61789-28-4), see also classification and toxicity of coal tar creosote (CAS No. 8001-58-9) (Japan Advanced Information Center of Safety and Health).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Since both its rat LD50 values (> 3100 mg/kg, > 4200 mg/kg and > 2000 mg/kg) and rabbit LD50 values (> 7950 mg/kg) (CICAD 62 (2004)) are higher than Category 4 guidance values, the substance was classified into "Not classified" using the JIS classification criteria (Category 5 or "Not classified" in the United Nations classification).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (room temperature) (CICAD 62 (2004))
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	In studies using rats, inhalation of the substance for 1 hour resulted in no mortality at the concentration of 0.033 ml/L air (38.6 mg/L/1h or 9.68 mg/L/4h) (its saturated vapour concentration). Without its LC50 being provided, classification is not possible.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	Based on the information that mild to severe irritation was detected in humans (CICAD 62 (2004)), the substance was classified into Category 2. The primary irritation index for creosote (the United States, 64-451B) is 6.1, and it is classified as a primary skin irritant (CICAD 62 (2004)).
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	In eye irritation tests using rabbits (CICAD 62 (2004)), a redness of the conjunctiva with congested vessels developed, and it healed within 7 days. Based on this report, the substance was classified into Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Category 2		Warning	H341: Suspected of causing genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Micronucleus tests using bone marrow of mice that underwent intraperitoneal administration (in vivo mutagenicity tests using somatic cells) (CICAD 62 (2004)) resulted in positive results. However, since information on in vivo genotoxicity tests using germ cells is not available, the substance was classified into Category 2. With respect to in vitro mutagenicity tests, positive results have been reported in Ames tests and mouse lymphoma assays while negative results were documented in chromosomal aberration tests using human lymphocytes (CICAD 62 (2004)).
6	Carcinogenicity	Category 1B		Danger	H350: May cause cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Since it is rated as Group 2A by the IARC, the substance was classified into Category 1B.
7	Reproductive toxicity	Category 1A		Danger	H360: May damage fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Examinations on children of male workers who were exposed to creosote indicated an increase in brain cancer and neuroblastoma (CICAD 62 (2004)). In addition, although this is information is on a substance related to the test substance, oral exposure in rats during the organogenetic period resulted in an increased rate of abnormalities in offspring such as a cleft palate, or syndactyly and ectrodactyly (ATSDR (2002)). Based on these results, the substance was classified into Category 1A.
8	Specific target organ toxicity - Single exposure	Category 3 （Narcotic effects）		Warning	H336: May cause drowsiness or dizziness (narcotic effects)	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ...	In 4-hour inhalation tests using rats, decreased respiration and a semicomatose condition were detected (CICAD 62 (2004)). Thus, the substance was classified into Category 3 (narcotic effects). Also, information on the effects of the test substance analog on respiratory tract irritation in humans is documented (HSDB (2003)), but detailed descriptions are not available.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	In the tests using rats that underwent oral administration for 1 to 5 weeks, suppressed body weight, changes in weights of the digestive organs such as small and large intestines, or changes in enzymes in the small intestine were detected (CICAD 62 (2004)). However, since information on the effects of this substance on other organs is not available, classification is not possible. With respect to substances related to this substance (ATSDR (2002)), its application is documented to be associated with decreased body weight, epithelial hyperplasia and chronic inflammation of the cecum, or atrophy of the thymus.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.