Chemical Name：propiconazole; (+)-1-[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole
CAS：60207-90-1

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Its rat LD50 of 1517 mg/kg bw (JMPR (2004)) is equivalent to Category 4.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Its rat LD50 of > 4000 mg/kg bw (JMPR (2004)) and its rabbit LD50 of > 6000 mg/kg bw (JMPR (2004)) fall under the "Not classified" category.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Not classified	-	-	-	-	Its rat LC50 of 5 mg/L (JMPR (2004)) falls under the "Not classified" category based on the JIS classification criteria (Category 5 or "Not classified" in the GHS classification). Its saturated vapour concentration is 1.84E-0.5 mg/L, which indicates that the experiment was conducted using dust (mist).
2	Skin corrosion/irritation	Not classified	-	-	-	-	In Draize tests using six rabbits, all animals developed skin erythema or edema, which were translated to scores between 1 and 2 (slightly irritating); these symptoms completely healed in 7 days (HSDB (2006)). In addition, in skin tests applied to 20 volunteers, it was concluded that there is no evidence of skin irritation by the substance (JMPR (2004)). Based on these results, the substance was classified into "Not classified".
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	In Draize tests using six rabbits, corneal irritation and conjunctival irritation were observed in 3 rabbits, which translates to scores 1 to 2 (minimal irritation); these symptoms completely healed in 72 hours (HSDB (2006)). Based on these results, the substance was classified into Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	Positive results were documented in skin sensitization tests (maximization tests) using guinea pigs (JMPR (2004)). In addition, the substance is rated as R43 in the EU classification. Based on these reports, it was classified into Category 1.
5	Germ cell mutagenicity	Not classified	-	-	-	-	The substance was classified into "Not classified" based on negative results given by the following studies: dominant lethal tests using mice that underwent oral administration (in vivo heritable mutagenicity tests using germ cells) (JMPR (2004)) and micronucleus tests using bone marrow cells of hamsters that underwent oral administration (in vivo mutagenicity tests using somatic cells) (JMPR (2004)). Regarding in vitro mutagenicity tests, only negative results were documented in Ames tests, mouse lymphoma assays, and chromosomal aberration tests using human lymphocytes in peripheral nerves (JMPR (2004)).
6	Carcinogenicity	Not classified	-	-	-	-	In 2-year oral administration (mixed diet) tests using rats, the substance was concluded to be non-carcinogenic in rats (JMPR (2004)). In contrast, in 18-month oral administration (mixed diet) tests using mice, a significant increase in incidences of hepatocellular adenoma (JMPR (2004)) was reported. Because no carcinogenicity was detected in rats and increased incidences of hepatic adenoma occurred only in mice, the probability of the substance being carcinogenic to humans is likely low. Thus, it was classified into "Not classified".
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In 2-generation reproduction tests using rats that underwent oral administration, a decreased survival rate of offspring was identified (JMPR (2004)). In addition, in oral exposure tests using rabbits conducted during the organogenetic period, miscarriage and premature birth were observed at the dose toxic to parental animals while no signs of teratogenicity were detected (JMPR (2004)). Based on these results, the substance was classified into Category 2. Also, in the tests using rats that were orally exposed during the organogenetic period, delayed ossification was discovered while no malformation was detected (JMPR (2004)).
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	No data available.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	In 28-day oral administration tests using rats, necrosis of the liver was reported at the dose of 450 mg/kg (90-day correction: 140 mg/kg), which is higher than Category 2 guidance doses (JMPR (2004)). In 13-week oral administration tests (mixed diet), no effects of administration were detected at >= 1200 ppm (76 mg/kg), which falls under Category 2 guidance doses, other than an increased liver weight and changes in erythrocyte parameters (JMPR (2004)). In 13-week oral administration tests using mice, a significant increase in liver weight and hepatocyte necrosis was reported at the dose of 850 ppm (121 mg/kg), which is higher than Category 2 guidance doses (JMPR (2004)). In 17-week oral administration tests, an increased liver weight and development of discolored foci were detected at 111 mg/kg. These reports support the effects of the substance on the liver. However, the effects of the substance were identified only at the doses higher than Category 2 guidance doses, and its effects in the range of guidance doses are uncertain. Thus, the substance was classified into "Classification not possible".
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since its 96-hour LC50 = 0.51 mg/L for crustaceans (mysids) (ECOTOX, 2008), the substance was classified into Category 1.
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since its classification for acute toxicity is Category 1, and it is not rapidly degradable (SRC: BioWin V4.10), the substance was classified into Category 1.