Chemical Name：(1-methyl-1,2-ethanediyl)bis[oxy(methyl-2,1-ethanediyl)] diacrylate
CAS：42978-66-5

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on its rat LD50 values of 3000-8100 mg/kg bw (OECD TG 401, GLP-compliant) and 6800 mg/kg bw (IUCLID (2000)), the substance was classified into "Not classified" using the JIS classification criteria (Category 5 or "Not classified" category in the United Nations classification).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on its rat LD50 of > 2000 mg/kg bw (IUCLID (2000)), the substance was classified into "Not classified" using the JIS classification criteria (Category 5 or "Not classified" category in the United Nations classification).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Not classified	-	-	-	-	Two rabbit tests (OECD TG 404, GLP-compliant) found that the substance is not irritating or slightly irritating (IUCLID (2000)). In two Draize tests using rabbits (GLP-compliant), both tests found that the substance is slightly irritating (Primary Irritation Index values were 0.8 and 1.0) (IUCLID (2000)). Thus, it was classified into "Not classified".
3	Serious eye damage/eye irritation	Category 2A		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	Two rabbit tests (one of them was a Draize test) found that the substance is severely irritating (IUCLID (2000), RTECS (2003)); furthermore, it is rated as Xi; R36/37/38. Thus, the substance was classified into Category 2A.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	Two maximization tests using guinea pigs (GLP-compliant) resulted in the substance being both sensitizing and not sensitizing (IUCLID (2000)). Since it is rated as R43 in the EU classification and Sh in the DFG's classification, it was classified into Category 1.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Classification is not possible due to lack of in vivo data. Regarding in vitro mutagenicity tests, Ames tests yielded negative results while chromosomal aberration tests using mouse lymphocytes gave positive results (IUCLID (2000)).
6	Carcinogenicity	Classification not possible	-	-	-	-	In 80-week dermal administration tests using mice, tumorigenesis in the skin or organs did not increase in animals exposed to the test substance at the doses of 100 mg/kg bw compared with control, indicating that it is not carcinogenic to the skin (IUCLID (2000)). On the other hand, in 20-week dermal administration tests using mice, administration of this substance at the doses of 50 or 100 mg/kg bw was associated with frequent occurrence of skin papilloma (IUCLID (2000)). Despite these studies documented, the substance was classified into "Classification not possible" due to lack of data on other animal species and administration routes other than dermal.
7	Reproductive toxicity	Classification not possible	-	-	-	-	In oral route exposure tests using rats conducted during the organogenetic period, it is documented that adverse effects on maternal, ovarian, uterine, litter and foetal parameters was observed (IUCLID (2000)). However, no further details are provided beyond this description. In addition, there is no information on fertility and sexual functions of parental animals. Thus, the substance was classified into "Classification not possible" due to insufficient data available. Also, in dermal route exposure tests using rats conducted during the organogenetic period, embryo and fetal toxicity were not detected (IUCLID (2000)).
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	In oral administration tests using rats, symptoms such as piloerection, abnormal gait, pallor of the extremities, increased salivation, and decreased respiratory rate were detected at the doses higher than Category 2 guidance values (IUCLID (2000)). However, since there is no information on the effects of doses that are within the range of guidance values, classification is not possible.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	Although 90-day dermal administration tests using rats (IUCLID (2000)) and 2-week dermal administration tests using rabbits (IUCLID (2000)) have been carried out, there is no information provided on symptoms observed in either study. Thus classification is not possible due to insufficient data available.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 2	-	-	H401: Toxic to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	Based on its 96-hour LC50 for fish (a species of Cyprinidae), which is > 4.5 mg/L and < 10 mg/L (IUCLID, 2000), the substance was classified into Category 2.
11	Hazardous to the aquatic environment （Long-term）	Category 2		-	H411: Toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Its classification for acute toxicity is Category 2, and there are no reliable results available on its rapid degradability. Based on this information, the substance was classified into "Category 2".