Chemical Name：pirimiphos-methyl (ISO); O-(2-diethylamino-6-methylpyrimidin-4-yl) O,O-dimethyl phosphorothioate
CAS：29232-93-7

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Its rat LD50 values are documented to be 2050 mg/kg, 1861 mg/kg or 1667 mg/kg (JMPR (1992); and 1450 mg/kg or 1250 mg/kg (HSDB (2002)). Based on these reports, the substance was classified into Category 4.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	There is a report that its rabbit LD50 is > 2000 mg/kg (EHC 63 (1986)). Its rat LD50 was 2000 mg/kg in one study (HSDB (2002)) while it was > 4592 mg/kg in another (RTECS (2007)). In addition, its rabbit LD50 is also reported to be > 2000 mg/kg (RTECS (2007)). Based on this information, the substance was classified into "Not classified" using the JIS classification criteria (Category 5 in the United Nations classification).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (room temperature)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Not classified	-	-	-	-	Based on its rat LC50 value of > 5.4 mg/L/4h (HSDB (2002)), the substance was classified into "Not classified" using the JIS classification criteria (Category 5 or "Not classified" category in the United Nations classification). Since its saturated vapour concentration is 0.002 mg/L at 20degC (GESTIS accessed in January 2009), the test was presumably carried out in a mist state.
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on the information that the substance was slight irritating to the skin of rabbits (HSDB (2002)), the substance was classified into "Not classified" using the JIS classification criteria (Category 3 in the United Nations classification).
3	Serious eye damage/eye irritation	Category 2		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	Based on the information that the substance was slight irritating to the eyes of rabbits (HSDB (2002)), the substance was classified into Category 2.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	Insufficient data available. It is documented that the substance is not sensitizing in guinea pigs (HSDB (2002)); however, details of the test could not be confirmed.
5	Germ cell mutagenicity	Not classified	-	-	-	-	Mostly negative results were obtained in micronucleus tests using the sperm of mice (JMPR (1992)), and in cytogenetical tests using bone marrow of rats that underwent single administration of 32, 102, or 320 mg/kg bw, or repeated administrations for 5 days (JMPR (1992)). That is to say that both in vivo mutagenicity tests using germ cells and in vivo mutagenicity tests using somatic cells gave negative results. Thus, the substance was classified into "Not classified". Regarding in vitro tests, one Ames test gave positive results (JMPR (1992)), while another Ames test (JMPR (1992)), mouse lymphoma assays (JMPR (1992)), in vitro cytogenetical tests using human lymphocytes, and cell transformation assays using renal cells of hamsters gave negative results (JMPR (1992)).
6	Carcinogenicity	Not classified	-	-	-	-	In 80-week repeated exposure tests / carcinogenicity tests using CFLP mice that were administered with up to 500 ppm of the substance in feed, no evidence of tumor induction was found (JMPR (1992)). Similarly, in 2-year repeated administration tests using Wistar SPF rats that were administered with up to 300 ppm in feed, frequencies of tumor induction were not different between control and treated groups (JMPR (1992)). Based on the conclusion by the JMPR (1992) that this substance does not appear to be carcinogenic, it was classified into "Not classified".
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In 4-generation tests using rats, a decreased mating behavior and pregnancy rates at the dose of 10 mg/kg/d were observed (JMPR (1992)). Based on this report, the substance was classified into Category 2. In addition, in female rats administered with the dose of 150mg/kg/d during the gestational period, though embryotic and fetal toxicity (slight evidence of delayed ossification in pes scores) was detected, no signs of teratogenicity were found (JMPR (1992)); in 3-generation tests using rats, no signs of reproductive toxicity were detected at the highest dose tested (5 mg/kg/d) (JMPR (1992)); in rats administered with 10 mg/kg/d during the gestational period, no signs of teratogenicity were detected (JMPR (1992)); and finally, in rabbits administered with 16 mg/kg/d during the gestational period, no signs of fetal toxicity or teratogenicity were found (JMPR (1992)).
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	Classification is not possible due to insufficient data available. There are reports that the substance may be associated with cholinesterase inhibition in humans, nausea, dizziness or confusion; in addition, it may cause respiratory paralysis or death at very high doses (HSDB (2002)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (nervous system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In the tests using both sexes of rats with each group of 25 rats given feed containing 8, 80 or 360 ppm of the substance for 90 days (conversion values: 0.4, 4 or 18 mg/kg/d, respectively), 41-88% of rats showed inhibition of plasma cholinesterase at the dose of 80 ppm, which is a Category 1 guidance dose. In addition, inhibition of brain cholinesterase was detected at the dose of 80 ppm or more, and this symptom did not improve after 4 weeks (JMPR (1992)). Furthermore, in other tests using rats, mice or dogs (JMPR (1992)), similar cholinesterase inhibition was reported. Thus, the substance was classified into Category 1 (nervous system). Also, there are no reported cases of serious toxic effects associated with doses that are within the range of guidance doses.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.