GHS Classification Result

Chemical Name:3-[2,4-dichloro-5-(1-methylethoxy)phenyl]-5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2(3H)-one; oxadiazon
CAS:19666-30-9

Result:
ID: 20A2262
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen and chlorine (but not fluorine), which are chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Its rat LD50 values of > 3500 mg/kg and 5000 mg/kg (HSDB, 2002) fall under the guidance values of "Not classified" category using the JIS classification criteria (Category 5 in the United Nations classification).
1 Acute toxicity (Dermal) Not classified - - - - Its rat LD50 values of > 2000 mg/kg (HSDB, 2002) and 5200 mg/kg (RTECS, 2007) fall under the guidance values of "Not classified" category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Although its rat LC50 of > 200 g/m3 is documented (RTECS, 2007), duration of exposure is not mentioned. Because of this and due to lack of other data, classification is not possible.
2 Skin corrosion/irritation Classification not possible - - - - It is documented that this substance causes slight damage to the skin in humans (HSDB, 2002). However, this document does not provide sufficient details necessary for classification. Thus, classification is not possible based only on this information.
3 Serious eye damage/eye irritation Classification not possible - - - - The substance is documented to be mildly or slightly irritating (HSDB (2002)). However, this document does not provide sufficient details necessary for classification. Thus, classification is not possible based only on this information.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Since neither in vivo tests nor in vitro mutagenicity tests using multiple indices are available, the substance was classified into "Classification not possible". As relevant information, positive results are reported in a chromosomal aberration test using cultured human lymphocytes (in vitro mutagenicity test) (RTECS, 2009).
6 Carcinogenicity Classification not possible - - - - In 105-week oral exposure tests using mice, TDLo was 11025 mg/kg/105W and tumorigenesis in the liver was documented (RTECS (2007)). However, this document does not provide necessary details. In addition, test data on other animal species are not available. As such, classification is not possible.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In oral administration tests using rats or rabbits conducted during the organogenetic period, any signs of teratogenicity were not detected (IRIS, 1991). In rats, though its toxicity to the offspring was documented, kinds of toxicity observed were not specified. On the other hand, 3-generation tests using rats that underwent oral administration (IRIS, 1991), fewer and lighter pups (parental toxicity not documented), and reduction in litter size were detected. Thus, the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Category 2 (blood, liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Oral administration tests using rats or mice, that were treated with 10 mg/kg, did not find any signs of toxic effects (HSDB, 2002). According to 2-week rat tests and 4-week mouse tests, TDLo was 2800 mg/kg (90-day conversion: 933 mg/kg), which is higher than Category 2 guidance doses; and documented observations include inhibition of enzymatic activities in terms of biochemistry, change in derivation, and change in weight of the liver (RTECS, 2007). In addition, in 2-year mixed diet tests using rats that underwent oral administration (doses: 10, 100, 1000 or 3000 ppm; unit-converted doses: 0.5, 5, 50 or 150 mg/kg), hepatotoxicity, hemolytic anemia or body weight changes were documented at the dose of 50 mg/kg, which falls under Category 2 guidance doses (IRIS (1991)). From these results, the substance was classified into Category 2 (blood and liver).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Based on its 96-hour LC50 of 0.27 mg/L for crustaceans (mysids) (Aquire, 2008), the substance was classified into Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its classification for acute toxicity is Category 1, and it is not rapidly degradable (non-biodegradable, BOD degradability: 1.6% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1979), the substance was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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