Chemical Name：2,2-bis(acryloyloxymethyl)butyl acrylate; trimethylolpropane triacrylate
CAS：15625-89-5

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Since its rat LD50 values are 3.84 to 7.01 ml/kg bw (4200 to 7700 mg/kg bw) (NTP GMM 3 (2005)), the substance was classified into "Not classified" (Category 5 or "Not classified" category in the United Nations classification).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on its rabbit LD50 values of 200-2000 mg/kg, 3.89-10.04 ml/kg (4280-11000 mg/kg), 5170 mg/kg (NTP GMM 3 (2005)), the substance was classified into "Not classified" (Category 5 or "Not classified" category in the United Nations classification).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	Since the Draize tests using rabbits resulted that the substance causes moderate irritation (IUCLID (2000), RTECS (2003)), and it is rated as Xi; R36/38 in the EU classification, the substance was classified into Category 2.
3	Serious eye damage/eye irritation	Category 2A		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	Since the Draize tests using rabbits resulted that the substance causes moderate irritation (IUCLID (2000), RTECS (2003)), and it is rated as Xi; R36/38 in the EU classification, the substance was classified into Category 2A.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	The substance was classified into Category 1 based on the following results: in maximization tests using guinea pigs, 42, 40, 50 (DFGOT vol. 16 (2001)), or 70% (NTP GMM 3 (2005)) of the tests accounted for positive reactions; and the substance was rated as Sh in the DFG's evaluation and R43 in the EU classification.
5	Germ cell mutagenicity	Not classified	-	-	-	-	Since peripheral blood micronucleus tests using mice that underwent dermal administration for 13 weeks (in vivo mutagenicity tests using somatic cells) resulted in negative reactions (NTP DB (accessed in February 2009), the substance was classified into "Not classified". Likewise, Ames tests (in vitro mutagenicity tests) gave negative results (NTP DB (accessed in February 2009)).
6	Carcinogenicity	Classification not possible	-	-	-	-	In 80-week dermal administration tests using mice, slight epilation of the skin in the applied area, acanthosis of the epidermis in 46 of 50 treated animals, and fibrosis of the dermis in 38 treated animals were observed, while tumorigenesis was not detected (NTP GMM 3 (2005)). Despite these results, the substance was classified into "Classification not possible" because test data using neither other animal species nor administration routes other than dermal are available.
7	Reproductive toxicity	Classification not possible	-	-	-	-	According to oral administration tests using rats treated during the organogenetic period, an increased post-implantation loss is observed (RTECS (2003)); however, since the results were based on a List 3 dataset, the substance was classified into "Classification not possible".
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	No data available.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	No data available.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.