GHS Classification Result

Chemical Name:desmedipham; ethyl 3-phenylcarbamoyloxyphenylcarbamate
CAS:13684-56-5

Result:
ID: 20A2255
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains oxygen which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on its rat LD50 value of 10250 mg/kg (EHC 64, 1986), the substance was classified into "Not classified".
1 Acute toxicity (Dermal) Not classified - - - - Based on its rabbit LD50 value of 2025 mg/kg (EHC 64, 1986), the substance was classified into "Not classified" using the JIS classification criteria (Category 5 in the United Nations classification).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Although its rat LC50 of > 7.4 mg/L (Gangolli (2nd Ed. 1999)) has been documented, the value is based on List 3 dataset and thus, the substance was classified into "Classification not possible". Since its saturated vapour pressure concentration is 4.82*10^-8mg/L, it was judged that the test was conducted using dust.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Neither in vivo data nor positive results in in vitro mutagenicity tests using several indices are available, classification is not possible. Also, negative results were gathered in in vitro mutagenicity tests including Ames tests and chromosomal aberration tests using human lymphocytes (Pesticide Safety Information (Japan Crop Protection Association), original literature: FOOD SANITATION RESEARCH vol. 51, No. 8)
6 Carcinogenicity Classification not possible - - - - In carcinogenicity tests using rats or mice that underwent mixed diet administration, no carcinogenicity was detected (Pesticide Safety Information (Japan Crop Protection Association), original literature: FOOD SANITATION RESEARCH vol. 51, No. 8). This result indicates that the substance is to be placed into "Not classified" category, but the result is based on a List 2 dataset; thus, the substance was classified into "Classification not possible".
7 Reproductive toxicity Classification not possible - - - - Negative results were obtained in both 2-generation reproductive tests using rats and teratogenicity tests using rats or chinchilla rabbits (Pesticide Safety Information (Japan Crop Protection Association), original literature: FOOD SANITATION RESEARCH vol. 51, No. 8). These results indicate that the substance is to be placed into "Not classified" category, but the result is based on a List 2 dataset; thus, the substance was classified into "Classification not possible".
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Category 2 (blood system) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In combined studies of repeated administration and carcinogenicity tests using rats, a tendency to anemia, and increase in reticulocytes and hemoglobin were observed in animal groups treated with 300 ppm (conversion value: 16 mg/kg/day) or higher (Pesticide Safety Information (Japan Crop Protection Association), original literature: FOOD SANITATION RESEARCH vol. 51, No. 8 (2001)). Thus, the substance was classified into Category 2 (blood system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since its 96h LC50 = 1.7 mg/L for fish (rainbow trout) (Aquire 2009), the substance was classified into Category 2.
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its classification for acute toxicity is Category 2, and no datasets on its rapid degradability are available, the substance was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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