GHS Classification Result

Chemical Name：nickel dihydroxide
CAS：12054-48-7

Result：
ID: 20A2254
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Since the substance is not water soluble (Merck 14th, 2006), or its water solubility is 0.013 g/100 cc in cold water (HSDB, 2003) or 0.00015 g/100g H2O at 20degC (Lide 88th, 2008), it is considered to be not water reactive. Therefore, the substance is classified into "Not classified".
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - It is an inorganic compound containing oxygen (but not halogen); classification is not possible due to lack of data.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on its rat LD50 values of 1500 mg/kg (male), 1700 mg/kg (female) (ECETOC TR No. 33 (1989)), and 1600 mg/kg (PATTY 5th, 2001), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Classification not possible - - - - Its rat LD50 of > 2000 mg/kg (RTECS, 2008) indicates that the substance is to be placed in "Not classified" category; however, since this dataset is thereof List 3 and no other datasets are available. Thus, classification is not possible due to lack of data.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Since its LC50 = 1200 mg/m3 (1.2 mg/L/4h) (RTECS (2008)) and it is rated as R20 in the EU classification, the substance was classified into Category 4.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ... 		Nickel or nickel compounds are rated as Category 2 for tracheal sensitization by the Japan Society for Occupational Health (2004) and Sah in MAK/BAT (2004); thus, the substance was classified into Category 1.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Nickel or nickel compounds are rated as Category 1 for skin sensitization by the Japan Society for Occupational Health (2004), Sah in MAK/BAT (2004), and R43 in the EU classification; thus, the substance was classified into Category 1.
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		According to classifications, nickel compounds are rated as Group 1 by the IARC (IARC vol. 49 (1990)); nickel compounds except for metallic nickel are rated as Category 1 by the Japan Society for Occupational Health (Recommendations of Occupational Exposure Limits (2008)); and nickel and nickel compounds are rated as A1 by the ACGIH (ACGIH (2008)). Based on these evaluations, the substance was classified into Category 1A. There are two studies in which effects of intramuscular administration on rats resulted in development of a sarcoma in both studies (IARC vol. 49 (1990)). This substance is rated as Carc. Cat 3; R40 in the EU classification (EU-Annex 1 (accessed in January 2009)).
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In an oral administration test using rats, symptoms such as decreased activity, ataxia and diarrhoea were observed as well as mortality being detected at 1500 mg/kg (male) and 1700 mg/kg (female) (ECETOC TR No. 33 (1989)), which fall under Category 2 guidance values. However, since details of the study are not clearly explained and no other test results are available, the substance was classified into the "Classification not possible" category.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information