GHS Classification Result

Chemical Name:dinitrogen tetraoxide
CAS:10544-72-6

Result:
ID: 20A2252
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - The substance, as dangerous transport goods, is treated as a gas (UN-1067) and is not explosive.
2 Flammable gases (including chemically unstable gases) Not classified - - - - Nonflammable (Hommel (1996); Weiss (1986)).
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Category 1 Danger H270: May cause or intensify fire; oxidizer P370+P376: In case of fire: Stop leak if safe to do so.
P220: Keep/Store away from clothing/.../combustible materials.
P244: Keep reduction valves free from grease and oil.
P403: Store in a well-ventilated place.
The substance is described as nitrogen dioxide in ISO-10156-2.
5 Gases under pressure Low pressure liquefied gas Warning H280: Contains gas under pressure; may explode if heated P410+P403: Protect from sunlight. Store in a well-ventilated place. Its critical temperature is 158degC.
6 Flammable liquids Not applicable - - - - It is a gas (GHS definition) and nonflammable (Hommel (1996); Weiss (1986)).
7 Flammable solid Not applicable - - - - Gas (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - The substance, as dangerous transport goods, is treated as a gas (UN-1067) and is not a self-reactive chemical product.
9 Pyrophoric liquids Not applicable - - - - It is a nonflammable (ERG (2008); Hommel (1996)) gas (GHS definition) that does not ignite spontaneously in contact with air at ordinary temperature.
10 Pyrophoric solids Not applicable - - - - Gas (GHS definition)
11 Self-heating substances and mixtures Not applicable - - - - Gas (GHS definition)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Gas (GHS definition)
13 Oxidizing liquids Not applicable - - - - Gas (GHS definition)
14 Oxidizing solids Not applicable - - - - Gas (GHS definition)
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gaseous substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - No data available.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Classification not possible - - - - Its LC50 values have been documented: 29 ppmV for rats, 50.1 ppmV for mice, and 84.3 ppmV for rabbits (RTECS (2008)). However, these datasets are insufficient since administration durations associated with these LC50 values are not provided.
1 Acute toxicity (Inhalation: Vapours) Not applicable - - - - Gas (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Not applicable - - - - Gas (GHS definition)
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since its skin corrosivity is documented in humans (HSDB (2002)), and it is rated as C; R34 in the EU classification, the substance was classified into Category 1.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
Since it is rated as C; R34 in the EU classification and it is known as a skin corrosive substance (HSDB 2002), the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In vivo chromosomal aberration tests using mouse spermatocytes (in vivo mutagenicity tests using germ cells) found negative results, while in vivo chromosomal tests using rat pneumocytes (in vivo mutagenicity tests using somatic cells) and in vivo DNA damage tests using mouse pnemocytes (in vivo genetic toxicity tests using somatic cells) found positive results (EHC 188 (1997)). Since in vivo genetic toxicity tests using germ cells are not available, the substance was classified into Category 2. Also, both Ames tests and in vitro mutagenicity tests using Chinese hamster cells also gave positive results (EHC 188 (1997)). In these toxicity tests, because N2O4 is the dimer of NO2, formed in equilibrium with NO2 molecules under the atmospheric pressure, and it readily disassociates to NO2 (EHC 188 (1997)). Thus, these results are considered to be of NO2, and not of N2O4.
6 Carcinogenicity Classification not possible - - - - There is no sufficient information to use as grounds for determining if NO2 exposure has a direct link to carcinogenicity. The toxicity test datasets considered were of NO2, and not of N2O4, because N2O4 is the dimer of NO2, formed in equilibrium with NO2 molecules under the atmospheric pressure, and it readily disassociates to NO2 (EHC 188 (1997)).
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system) Warning H371: May cause damage to organs (respiratory system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
The cases of Silo Filler's disease, an occupational pulmonary disease associated with acute exposure to NO2, were documented (HSDB (2002)). Also, symptoms such as nasal irritation, bronchospasm, bronchiolitis obliterans, and pulmonary fibrosis were observed in humans (HSDB (2002)). In addition, pulmonary edema with possible subacute lesions in the lungs was suggested to occur in humans who are exposed to 50 ppm for 60 minutes (HSDB (2002). Based on this information on human toxicity, the substance was classified into Category 2 (respiratory system). Also, there are reports on respiratory symptoms such as pulmonary edema that developed in rats, mice or rabbits (RTECS (2008)). These reports are based on the effects of NO2, and not of N2O4, because N2O4 is the dimer of NO2, formed in equilibrium with NO2 molecules under the atmospheric pressure, and it readily disassociates to NO2 (EHC 188 (1997)).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In inhalation tests using rabbits that were exposed to the substance 24 hours a day for 3 to 4 months (> 90 days), emphysema was documented to occur at the doses of 8 or 12 ppm (EHC 188 (1997)). These doses fall under the range of corrected guidance values for Category 1 (<= 12.5 ppm). In addition the cases of Silo Filler's disease, an occupational pulmonary disease (HSDB (2002)) were documented, and symptoms such as nasal irritation, bronchospasm, bronchiolitis obliterans, and pulmonary fibrosis were observed in humans (HSDB (2002)). These reports are based on the effects of NO2, and not of N2O4, because N2O4 is the dimer of NO2, formed in equilibrium with NO2 molecules under the atmospheric pressure, and it readily disassociates to NO2 (EHC 188 (1997)).
10 Aspiration hazard Not applicable - - - - Gas (GHS definition)

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information