GHS Classification Result

Chemical Name:calcium chloride
CAS:10043-52-4

Result:
ID: 20A2251
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Not classified - - - - Nonflammable (IUCLID (2000)).
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Nonflammable (IUCLID (2000)).
11 Self-heating substances and mixtures Not classified - - - - Nonflammable (IUCLID (2000)).
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - No data available.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - An inorganic compound containing chlorine (but not fluorine, bromine, iodine or oxygen). Classification is not possible due to lack of data.
15 Organic peroxides Not applicable - - - - Inorganic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available (a reaction with zinc produces hydrogen)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Of two rat LD50 values documented: 2045 mg/kg for males and 1940 mg/kg (females) (OECD TG 401) (SIDS (accessed in December 2008)), the female LD50 value was used as grounds for classifying the substance into Category 4.
1 Acute toxicity (Dermal) Not classified - - - - Based on its rabbit LD50 > 5000 mg/kg (SIDS (accessed in December 2008)), the substance was classified into "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Based on its rat LD50 value of >= 0.16 mg/L (SIDS (accessed in December 2008)), a proper category cannot be determined; thus, classification is not possible.
2 Skin corrosion/irritation Classification not possible - - - - Rat tests (OECD TG 404 GLP) found that the substance in forms of anhydrides and dihydrates are not irritating, while those of hexahydrates were slightly irritating (SIDS (accessed in December 2008)). On the other hand, several workers who package calcium chloride developed erythema and peeling of the skin, indicating that calcium chloride has a powerful irritant action on the skin and mucous membranes in humans (SIDS accessed in December 2008). Because of inconsistencies between the results from animal tests (Not classified) and the positive human cases, the substance was classified into "Classification not possible".
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
Several workers who package calcium chloride developed erythema and peeling of the skin, indicating that calcium chloride has a powerful irritant action on the skin and mucous membranes in humans (SIDS accessed in December 2008); thus, the substance was classified into Category 1. As additional information, rat tests (OECD TG 404 GLP) found that the substance in forms of anhydrides and dihydrates were not irritating, while those of hexahydrates were slightly irritating (SIDS (accessed in December 2008)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Classification is not possible due to lack of information such as results from in vivo mutagenicity tests and in vitro mutagenicity tests using several indices. Also, Ames tests and mutagenicity tests using CHL cells (both are in vitro mutagenicity tests) resulted in negative outcome (SIDS (accessed in December 2008)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In developmental toxicity tests using rats or mice that underwent forced oral administration (OECD TG 414), signs of developmental toxicity were not found (SIDS (accessed in December 2008)). However, since these tests lack data on fertility and reproductive functions of parental animals, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation) Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
In inhalation tests using rats that received doses of 0.04 or 0.16 mg/L, several symptoms indicating respiratory system irritation were detected (SIDS (accessed in December 2008)); thus, the substance was classified into Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Category 2 (blood system) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In oral administration tests using rats, no toxic effects have been observed regardless of doses in any of several tests conducted. However, in inhalation tests using rats that received doses of 43.1 mg/m3/4 hours/day (5 days/week, 4 months) (6 hour conversion value: 0.03 mg/L), the following marked toxic symptoms were observed: decrease in the number of leukocytes, phagocytic activity in blood, lysozyme level in serum, and catalase activity, plasma recalcification, shortening of clotting, clot retraction, an increase in peroxidase activity. Since most of these symptoms did not improve after the observational period (SIDS (2008)), the substance was classified into Category 2 (blood system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Its LC50 and EC50 were >= 100 mg/L for fish, algae or crustaceans in any of the tests conducted (SIDS 2005), the substance was classified into "Not classified".
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since its classification for acute toxicity is "Not classified," and it is water soluble (water solubility = 745 g/L, SIDS 2005), the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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