GHS Classification Result

Chemical Name:oxygen
CAS:7782-44-7

Result:
ID: 20A2244
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Gas (GHS definition)
2 Flammable gases (including chemically unstable gases) Not classified - - - - A nonflammable gas (Ullmanns (E) (6th, 2003)).
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Category 1 Danger H270: May cause or intensify fire; oxidizer P370+P376: In case of fire: Stop leak if safe to do so.
P220: Keep/Store away from clothing/.../combustible materials.
P244: Keep reduction valves free from grease and oil.
P403: Store in a well-ventilated place.
According to the UNRTDG, the substance is rated as Division 2.2 (5.1) in Classes 3 and 4 of the dangerous goods list.
5 Gases under pressure Compressed gas Warning H280: Contains gas under pressure; may explode if heated P410+P403: Protect from sunlight. Store in a well-ventilated place. Under the standard pressure, since its boiling point is -182.96degC (Ullmanns (E) (6th, 2003) vol. 14), it completely gasifies at 20degC. Its critical temperature is -118.95degC (Merck (14th, 2006)), which is <= -50.
6 Flammable liquids Not applicable - - - - Gas (GHS definition)
7 Flammable solid Not applicable - - - - Gas (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Gas (GHS definition)
9 Pyrophoric liquids Not applicable - - - - Gas (GHS definition)
10 Pyrophoric solids Not applicable - - - - Gas (GHS definition)
11 Self-heating substances and mixtures Not applicable - - - - Gas (GHS definition)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Gas (GHS definition)
13 Oxidizing liquids Not applicable - - - - Gas (GHS definition)
14 Oxidizing solids Not applicable - - - - Gas (GHS definition)
15 Organic peroxides Not applicable - - - - Gas (GHS definition)
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gaseous substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - No data available.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not classified - - - - Humans ordinarily inhale it at all times.
1 Acute toxicity (Inhalation: Vapours) Not applicable - - - - Gas (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Not applicable - - - - Gas (GHS definition)
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Classification is not possible due to lack of in vivo data. Although positive results have been yielded in chromosomal aberration tests using human lymphocytes, chromosomal aberration tests using CHO and CHL cells, and Mutation tests using CHL cells, these results were based on high concentration exposure.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In high-pressure oxygen exposure tests using hamsters or rabbits during the organogenetic period, hamsters that inhaled high concentration of oxygen exhibited umbilical hernia, exencephaly, spina bifida, or limb deficiencies (Birth Defects (3rd, 2000)). In rabbits, fusion and resorption, deformation, eye deficiencies, frequent fetal mortality, and low developmental rates in premature infants were recognized (Birth Defects (3rd, 2000)). Thus, the substance was classified into Category 2. There are no data on sexual functions and fertility of parental animals.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation) Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
Rats exposed to 100% concentration of oxygen displayed bronchiolar and vascular constriction in 24 hours (PATTY (5th, 2001)); rabbits exposed to 100% concentration of oxygen developed conditions such as decreased lung capacity, decreased phospholipids (surfactant), or pulmonary edema in 24 to 96 hours (PATTY (5th, 2001)); and rats exposed to 95% concentration of oxygen caused reduction of the surfactant (PATTY (5th, 2001)). However, these observations were made at doses higher than the range of guidance values. In humans, exposure to 95% concentration of oxygen was associated with coughing within 4 hours (PATTY (5th, 2001)). Similarly, exposure to 90-95% concentrations of oxygen was associated with coughing within 3 hours (HSDB (2007)). From these human results, the substance was classified into Category 3 (respiratory tract irritation). Transient impairment of visual fields and visual acuity have been reported in association with hyperbaric O2 (PATTY (5th, 2001)).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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