GHS Classification Result

Chemical Name:sodium hydrogensulphate
CAS:7681-38-1

Result:
ID: 20A2242
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Not classified - - - - Nonflammable (Hommel (1996)).
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Nonflammable (Hommel (1996)).
11 Self-heating substances and mixtures Not classified - - - - Nonflammable (Hommel (1996)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Its water solubility has been measured (Merck (14th, 2008), Lide (88th, 2008)); it does not strongly react with water at ordinary temperatures.
13 Oxidizing liquids Not applicable - - - - Liquid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available.
15 Organic peroxides Not applicable - - - - Inorganic substance
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on its rat LD50 value of 2490 mg/kg (IUCLID (2000)), the substance was classified into "Not classified" using the JIS classification criteria (Category 5 in the United Nations classification).
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - In two rabbit tests (OECD guidelines 404, GLP-compliant), the substance was found to be not irritating (IUCLID (2000)). Thus, it was classified into "Not classified".
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
In 24-hour exposure tests using rabbits, the substance was evaluated to be irritating (IUCLID (2000); OECD guidelines 405, GLP-compliant), and was classified into Category 2. It is rated as R41 in the EU classification (equivalent to Category 1) (EU-Annex 1, accessed in December 2008).
4 Respiratory sensitization Classification not possible - - - - In double-blind tests in humans (IUCLID (2000)), inhalation exposure to four kinds of sulfuric acid compounds including this substance resulted in respiratory system conductance and air flow in asthma patients markedly decreased. However, since this substance cannot be identified as the definite cause of the toxic symptom observed, the substance was classified into "Classification not possible".
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - In vivo mutagenicity tests using mice (specific locus tests) yielded negative results (IUCLID (2000)); however, the test substance was sodium bisulfite (CAS No. 7631-90-5), not sodium hydrogensulphate. Thus, the substance was classified into "Classification not possible" due to lack of data. Information on in vitro tests was not available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Since its 48h EC50 = 190 mg/L for crustaceans (Daphnia magna) (IUCLID 2000), the substance was classified into "Not classified".
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since its classification for acute toxicity is "Not classified," and it is water soluble (water solubility = 1080 g/L, IUCLID 2000), the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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