GHS Classification Result

Chemical Name：uranium
CAS：7440-61-1

Result：
ID: 20A2237
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Category 1 Danger H250: Catches fire spontaneously if exposed to air P335+P334: Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P370+P378: In case of fire: Use ... for extinction.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P222: Do not allow contact with air.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P422: Store contents under ... 		Uranium ignites spontaneously when broken down into small pieces (Lide (84th, 2003)). Dust of uranium metal ignite at ordinary temperature (HSDB (2006)). Its minimum flashing point is 20degC (dust) (HSDB (2006)). Based on these descriptions, the substance was classified into Category 1.
11 Self-heating substances and mixtures Not applicable - - - - It is classified into pyrophoric solids.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Based on the information that it is not water soluble (HSDB (2005), IUCLID (2000)), the substance was classified into "Not classified".
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Inorganic substance containing no oxygen and halogen atoms
15 Organic peroxides Not applicable - - - - Not an organic compound.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - No data available.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - Although uranium metal and uranium dioxide are not considered to be chemically irritating to the eyes, both are abrasive and could cause physical damage (IUCLID (2000)). However, since specific data are not available, classification is not possible.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Category 1 Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since it is rated as A1 by the ACGIH (2001), the substance was classified into Category 1. The following have been documented as human epidemiological information: 1) excessive mortality by lung cancer or central nervous system cancer among 18869 white males who worked at a uranium enrichment plant, 2) confirmation of excessive mortality by lung cancer, central nervous system cancer, renal cancer, lymphosarcomas and multiple myeloma in cohorts of the plant workers in follow-up surveys, and 3) confirmation of excessive mortality by esophageal cancer, laryngeal cancer, all respiratory diseases and pneumonia among 2731 males who worked at other uranium refining and processing facility (ACGIH (2001)).
7 Reproductive toxicity Classification not possible - - - - Although there are reports on animal reproductive and developmental toxicity tests on uranium compounds (uranyl nitrate and uranyl acetate) (ATSDR (1999)), they are not on uranium metal. In addition, there are research results suggesting the effects of alpha radiation on Y chromosome as indicated by that fact that uranium mine workers have many female children relative to male children; however, it is uncertain if the effects are due to uranium (ATSDR (1999)). Overall, classification is not possible due to lack of data on uranium metal.
8 Specific target organ toxicity - Single exposure Category 1 (kidney) Danger H370: Causes damage to organs (kidney) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In animal experiments, systemic toxicity (oral, dermal, and inhalation) of uranium compounds (uranyl acetate and uranyl nitrate) has been documented (ATSDR (1999)); however, the study is not of uranium metal. Similarly, systemic toxicity of uranium compounds (uranyl acetate) when administered to humans has been documented (ATSDR (1999)); however the study is not of uranium metal. According to the ACGIH, uranium exposure in all animals and humans causes acute toxicity, and it causes necrosis of the proximal tubules, loop of Henle and collecting tubules, accompanied with loss of functions of the kidney, the main target organ of this substance (ACGIH (7th, 2001)); thus, the substance was classified into Category 1 (kidney).
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney) Danger H372: Cause damage to organs through prolonged or repeated exposure (kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		According to the ACGIH, uranium exposure in all animals and humans causes acute toxicity, and it causes necrosis of the proximal renal tubules, loop of Henle or collecting tubules, accompanied with loss of functions of the kidney, the main target organ of this substance (ACGIH (7th, 2001)); thus, the substance was classified into Category 1 (kidney).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Classification not possible due to lack of data.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - Classification not possible due to lack of data.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information