GHS Classification Result

Chemical Name:disodium metasilicate
CAS:6834-92-0

Result:
ID: 20A2235
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Not classified - - - - Nonflammable (SIDS (accessed in December 2008), ICSC (J) (2004)).
8 Self-reactive substances and mixtures Classification not possible - - - - No data available.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - It is nonflammable and not pyrophoric (SIDS (accessed in December 2008), ICSC (J) (2004)).
11 Self-heating substances and mixtures Not classified - - - - Nonflammable.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Its water solubility is 200 g/L (20degC) (IUCLID (2000)) and it is stable in contact with water.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on its rat LD50 values: 1750 (male), 1152-1349 (both sexes), 800, and 600 mg/kg bw (SIDS (accessed in December 2008)) and 1280 mg/kg (PATTY (5th, 2001)), the substance was classified into Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
In several 4-hour skin irritation tests using rabbits (OECD guidelines 404; SIDS (accessed in December 2008)), necrosis was observed in the skin and the substance was concluded to be corrosive. In addition, it is rated as C (corrosive)?R34 in the EU classification. Based on this information, the substance was classified into Category 1.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
Since the substance is documented to be corrosive in rabbit eye tests (IUCLID (2000)) and it is a skin corrosive substance (Category 1), the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Negative results were obtained in the Local Lymph Node Assay using mice (OECD guidelines 429). In addition, there is a case report on hives developed by contact in a human, and a report that the same person developed an ulcer and a wheal by a patch test (30 people in control groups showed a negative reaction) (SIDS (accessed in December 2008)). However, classification is not possible due to lack of data.
5 Germ cell mutagenicity Not classified - - - - Based on negative results obtained in chromosomal aberration tests using mouse bone marrow cells (in vivo mutagenicity tests using somatic cells) (SIDS (accessed in December 2008)), the substance was classified into "Not classified". In vitro mutagenicity tests (Ames tests) also yielded negative results (SIDS (accessed in December 2008)).
6 Carcinogenicity Classification not possible - - - - In both 14-month and 2-year oral administration tests using rats (SIDS (accessed in December 2008), IUCLID (2000)), no signs of carcinogenicity were detected. Classification is not possible based on this dataset alone, however, as data on other animal species are not available.
7 Reproductive toxicity Classification not possible - - - - Oral exposure of mice during the gestational period showed no effects on development of their offspring (SIDS (accessed in December 2008)). However, due to lack of data on sexual functions and fertility of parental animals, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 2 (nervous system) Warning H371: May cause damage to organs (nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
In oral administration tests using rats (doses: 538-2000 mg/kg bw for males, and 910-2600 mg/kg bw for females), lethargy, increased breathing frequency, platycoria, and cramps were observed (SIDS (accessed in December 2008)). In other oral administration tests using rats (dose: 1750 mg/kg bw), apathy, staggering gait, and dyspnoea were observed (SIDS (accessed in December 2008)). In addition, in oral administration tests using mice (doses: 500-1920.8 mg/kg for males, and 500-1372 mg/kg for females) (SIDS (accessed in December 2008) lethargy was observed. Since nervous symptoms such as lethargy, cyanosis, platycoria, dyspnoea, and paralysis of hind legs were observed at the doses that fall under Category 2 guidance values, the substance was classified into Category 2 (nervous system).
9 Specific target organ toxicity - Repeated exposure Not classified - - - - In 3-month tests using rats that underwent oral administration in drinking water (tests similar to those of OECD TG408) (doses: 200, 600 or 1800 ppm (26.4, 76.2 or 227.1 mg/kg/day for males, and 32.1, 97.6 or 237.2 mg/kg/day for females)), NOAEL was > 227-237 mg/kg bw, which was higher than Category 2 guidance values; no effects of administration were observed. Similarly, in other 3-month tests using rats that underwent oral administration in drinking water (doses: 750, 1500 or 3000 ppm (23, 47 or 110 mg/day for males, and 21, 37 or 84 mg/day for females)), no effects of administration were observed. In addition, in 3-month tests using mice that underwent oral administration through drinking water (doses: 300, 900 or 2700 ppm for males, and 333, 1000 or 3000 ppm for females), NOAEL was 260-284 mg/kg bw, which was higher than Category 2 guidance values; no notable effects were observed at the highest dose tested other than an increase in liver weight and a decreased leukocytes in females. Since none of the tests found any effects at the doses within Category 2 guidance values, the substance was classified into "Not classified".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Since its 96h LC50 = 210 mg/L for fish (zebra fish) (IUCLID 2000), the substance was classified into "Not classified".
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since it is not sparingly soluble in water (water solubility: > 200 g/L, IUCLID 2000) and its classification for acute toxicity is "Not classified," the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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