GHS Classification Result

Chemical Name：2,2',2"-(hexahydro-1,3,5-triazine-1,3,5-triyl)triethanol; 1,3,5-tris(2-hydroxyethyl)hexahydro-1,3,5-triazine
CAS：4719-04-4

Result：
ID: 20A2231
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid at room temperature (20 degC)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid at room temperature (20 degC)
5 Gases under pressure Not applicable - - - - Liquid at room temperature (20 degC)
6 Flammable liquids Classification not possible - - - - No data available.
7 Flammable solid Not applicable - - - - Liquid at room temperature (20 degC)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid at room temperature (20 degC)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid at room temperature (20 degC)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on its rat LD50 values of 580 and 928 mg/kg bw (DFGOT vol. 2, 1991), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Classification not possible - - - - Its rat LD50 is documented to be > 2000 mg/kg (RTECS (2003)). Although this dataset indicates that the substance is to be rated as "Not classified", it is a List 3 dataset. Thus, the substance was classified into "Classification not possible".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (room temperature)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Since there was a description that the substance was moderately to severely irritating in rabbit tests (DFGOT vol. 2 (1991)), the substance was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Since there was a description that the substance was sensitizing (100 % in positive rates) in skin sensitization testes using guinea pigs (DFGOT vol. 2 (1991)), and it was rated as Xi; R43 in the EU classification, the substance was classified into Category 1.
5 Germ cell mutagenicity Not classified - - - - Since the micronucleus tests using mice that underwent oral, dermal or hypodermic administration (DFGOT vol. 2 (1991)) (in vivo mutagenicity tests using somatic cells) yielded negative results, the substance was classified into "Not classified". In Ames tests (in vitro mutagenicity tests), both negative and positive results have been obtained (NTP DB (accessed in December 2008)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In a 24-hour dermal administration test, rabbits were applied with 2.2 g/kg bw, 3.48 g/kg bw, or 5.53 g/kg bw?the doses that fall under the "Not classified" category. In this test, there is a description that erythema, damage to the skin and a decreased hematocrit values, and a decrease in erythrocytes and leukocytes were observed. However classification is not possible due to lack of data.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - It was documented that no pathological changes caused by the substance were observed in the 5-week inhalation tests using guinea pigs (8 hours / day and 5 days / week) (DFGOT vol. 2 (1991). However, classification is not possible based on this dataset alone since it does not provide sufficient information on exposure concentrations, etc.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Based on its 48-hour EC 50 of 26.1 mg/L for crustaceans (Daphnia magna) (ECOTOX, 2008), the substance was classified into Category 3.
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since its classification for acute toxicity is Category 3 and it is not rapidly degradable (SRC: BioWin V4.10), the substance was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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