GHS Classification Result

Chemical Name:trimethylenediaminetetraacetic acid
CAS:1939-36-2

Result:
ID: 20A2223
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on its rat LD50 of 1600 mg/kg bw (RTECS, 2000: the original literature is OTS0546344, the National Technical Information Service (NTIS)), the substance was classified into Category 4. In addition, it is rated as R22 in the EU classification (EU-Annex 1, accessed in January 2009), which is equivalent to Category 3 or 4.
1 Acute toxicity (Dermal) Classification not possible - - - - Its guinea pig LD50 value is > 1000 mg/kg bw (RTECS, 2000: the original literature is OTS0546344, the National Technical Information Service (NTIS)); since a decision cannot be made between Category 4 and the "Not classified" category, the substance was classified into "Classification not possible".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - It is rated as R41 in the EU classification (EU-Annex 1, accessed in January 2009), which is equivalent to Category 1. However the substance was classified into "Classification not possible" due to lack of data.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In dermal administration tests using guinea pigs, the results were limited to the description that "a decrease in body weight and a decrease in body weight gain were observed" (RTECS, 2000: the original literature is OTS0546344, the National Technical Information Service (NTIS)); the information is limited to this description. The substance was classified into "Classification not possible" due to lack of data.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In 2-week oral administration tests using rats, effects on the lung and respiratory system were observed, but the TDLo was 14000 mg/kg/2 weeks (90-day correction dose: approximately 156 mg/kg/day), which falls under the guidance values for the "Not classified" category. Similarly, in 29-day oral administration tests using rats, effects on the gastrointestine were observed, but the TDLo is 21000 mg/kg/29 days (90-day correction dose: approximately 233 mg/kg/day), which falls under the guidance values of "Not classified" category. Furthermore, in 14-week oral administration tests using rats, effects on the kidney were observed, but the TDLo was 21000 mg/kg/14 weeks (dose per day: approximately 214 mg/kg/day), which falls under the guidance values of "Not classified" category. Based on these test results (all of which were cited from RTECS, 2000: the original literature is OTS0546344, the National Technical Information Service (NTIS)), the substance is considered to be rated as "Not classified". However, in conclusion, it was classified into "Classification not possible" due to lack of data, as a detailed description regarding its effects on organs is not available and only the oral route was tested and not other administration routes.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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