GHS Classification Result

Chemical Name:4-chloro-o-cresol; 4-chloro-2-methyl phenol
CAS:1570-64-5

Result:
ID: 20A2221
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Its autoignition point is 520degC (Hommel (1996)), which is >= 70degC.
11 Self-heating substances and mixtures Classification not possible - - - - Its melting point is 51degC (Howard (1997), Lide (88th, 2008), HODOC (3rd, 1997), HSDB (2003); Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine and oxygen (but not fluorine), which are chemically bonded only with carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on its rat LD50 values of 2650, 2700, and 3195 mg/kg (SIDS (accessed in December 2008)), the substance was rated as "Not classified" using the JIS classification criteria (Category 5 in the United Nations classification).
1 Acute toxicity (Dermal) Not classified - - - - Based on its rat LD50 value of 2240 mg/kg (OECD TG401, GLP-compliant) (SIDS (accessed in December 2008)), the substance was rated as "Not classified" using the JIS classification criteria (Category 5 in the United Nations classification).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Its saturated vapour pressure concentration is 17 mg/m3 (the unit converted). Since its rat LC50 values of 900 mg/m3/4h and > 30000 mg/m3/4h (SIDS (accessed in December 2008)) are higher than its saturated vapour pressure, the substance was classified into Category 3 using criteria for mist, GLP-compliant data and lower LC50 value.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the rabbit tests (OECD TG404, GLP-compliant), the substance was evaluated to be highly irritating and its Primary Dermal Irritation Index value was 8 (which is the maximum score) (SIDS (accessed in December 2008)). In other two tests using rabbits, the substance was concluded to be corrosive (IUCLID (2000)). Based on these results, the substance was classified into Category 1. In other tests using unknown animal species, necrosis was detected 1 minute after the exposure (SIDS (accessed in December 2008), BUA (Report 134, 1993)). Although these results indicate a more refined classification of the substance into Category 1A, further classification was not considered due to lack of information on the species and quantity of animals tested.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
Using rabbits, the substance has been documented to be strongly corrosive, and symptoms including hyperemia, and oedema and opacity of the cornea 1 hour after the exposure were detected. These symptoms lasted for 8 days and, additionally, staphyloma were observed (SIDS (accessed in December 2008)). Furthermore, in two other tests using rabbits, the substance was found to be irritating (IUCLID (2000)); and it is rated as Category 1 for skin corrosion and irritation. Thus, the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - In guinea pigs (maximization tests: OECD TG406, GLP-compliant, Buehler tests: non-GLP), the substance was evaluated to be not sensitizing (SIDS (accessed in December 2008)). Thus, it was classified into "Not classified".
5 Germ cell mutagenicity Not classified - - - - Since in vivo mutagenicity tests using mouse somatic cells (micronucleus tests) (SIDS (accessed in December 2008)) yielded negative results, the substance was classified into "Not classified". Although positive results were found in micronucleus tests conducted long time ago, the EU-RAR determined that the negative results obtained from above mentioned tests were more reliable. As additional information, in vitro mutagenicity tests (chromosomal aberration tests using Chinese hamsters) yielded positive results (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in December 2008).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In combined repeated oral dose toxicity study with the reproduction/developmental toxicity tests using both female and male rats (20-day forced oral administration during a 2-week period before mating and the gestation period: OECD TG422, GLP-compliant), reproductive or developmental toxicity was not observed (SIDS (accessed in December 2008)). However, since the information on teratogenicity of the offspring was not available, the substance was classified into "Classification not possible".
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects) Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
In dermal administration tests using rats of both sexes (1667-2880 mg/kg: OECD TG402), depressions and paresis were observed (SIDS (accessed in December 2008)). Thus, the substance was classified into Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In 28-day oral route tests using rats that received doses of 0-1000 mg/kg, epithelial hyperplasia in the mucosa of the urinary bladder was observed in the animal groups of both sexes that received 250 mg/kg (90-day correction value: 38.9 mg/kg/day); hyperplasia of squamous epithelium in the forestomach mucosa was detected in males; and a total serum bilirubin in males and relative weight of the kidney in females increase. However, the change in forestomach is thought to be caused by irritation to the digestive tracts, and the change in the urinary bladder is thought to be caused by a reactive increase by metabolites (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in December 2008). In other 28-day oral route tests using rats that received doses of 0-500 mg/kg, necrosis in the small intestine mucosa was detected in the animal groups that received 100 mg/kg (90-day correction value: 77.8 mg/kg) (SIDS (accessed in December 2008)). In combined repeated oral dose toxicity study with the reproduction/developmental toxicity tests using rats that received doses of 0-600 mg/kg bw for 40-45 days (OECD TG422, GLP-compliant), the LOEL was 600 mg/kg bw (90-day correction values: 266-300 mg/kg), which is considered to fall under "Not classified" category (SIDS (accessed in December 2008). Based on these results, the substance was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its 48-hour LC50 = 0.29 mg/L for crustaceans (Daphnia magna) (SIDS, 1998), the substance was classified into Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its classification for acute toxicity is Category 1, and it is not rapidly degradable (non-biodegradable, BOD degradability: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1982)), the substance was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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