GHS Classification Result

Chemical Name：4,4'-carbonimidoylbis[N,N-dimethylaniline]
CAS：492-80-8

Result：
ID: 20A2204
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Since its rat LD50 = 1100 mg/kg (DFGOT vol. 4, 1992), the substance was classified into Category 4. In the EU classification, the substance is classified into R22. For classifications of auramine hydrochloride, refer to ID694 auramine hydrochloride (NITE (accessed in February 2009).
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available. In rabbit tests, auramine hydrochloride (CAS: 2465-27-2) was not observed to cause irritation (DFGOT vol. 4, 1992).
3 Serious eye damage/eye irritation Classification not possible - - - - Since no animal test data are available, the substance was classified into "Classification not possible". However, in the EU classification, the substance has been classified into Xi; R36. The data on auramine hydrochloride applied on rabbits (CAS: 2465-27-2) showed that the substance caused severe irritation, which however, healed within 8 days (DFGOT vol. 4, 1992).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - Two intraperitoneal administration tests and one oral administration test, that were conducted as mouse micronucleus tests (in vivo mutagenicity tests), have been reported, and they all yielded negative results (DFGOT vol. 4 (1992)). Thus, the substance was classified into "Not classified" (Five mouse micronucleus tests (ip or po) were conducted in Japan and all yielded negative results (mutation Res., 389, 3-122, 1977)). Both Ames tests and chromosomal aberration tests using CHO cells, which were conducted as in vitro mutagenicity tests, yielded negative results (both tests cited in DFGOT vol. 4 (1992)).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In 87-week oral administration tests using rats, 92% of treated animals developed liver cancer 4-35 weeks after administration (IARC vol. 1, 1972; HSDB, 2003). Similarly, in 9-month oral administration tests, malignant hepatoma was observed at concentrations of 1500 and 2000 mg/kg (DFGOT vol. 4, 1992). In addition, in 52-week oral administration tests using mice, frequent cases of hepatoma (auramine-treated/control = 7/0) and lymphoma (auramine-treated/control = 11/5) were observed relative to control (IARC vol. 1, 1972; DFGOT vol. 4, 1992; HSDB, 2003). Furthermore, according to existing classifications for carcinogenicity, the substance is rated as Group 2B by the Japan Society for Occupational Health, Group 2B (technical-grade) by the IARC, and 3 by the EU. Based on these ratings, the substance was classified into Category 2.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In oral administration tests using rats, a substance containing a low concentration of auramine (the subsntance consisted of 87% dyestuff with remainder including NaCl, Na2SO4, and traces of Michler's ketone) was applied at either 400 ppm (90-day conversion: 60 mg/kg/day), a concentration that falls under Category 2, for four weeks, or at 200 ppm (10 mg/kg/day) for 90 days or for two years- no toxic effects were observed in any of the tests (DFGOT vol. 4, 1992). On the other hand, in 9-month oral administration tests using rats that received 300, 500, 1000, 1500, or 2000 mg/kg/day, which are above Category 2 guidance doses, the following changes were noted at the dose of 2000 mg/kg: cirrhosis, adenofibrosis, bile duct proliferation, and mataplastic changes of the liver. Similar changes were also detected after the application of 1500 mg/kg. Foci of modified hepatocytes were noted after 3 months at doses of 1500 and 2000 mg/kg, after 6 months at 500 mg/kg, and after 9 months at 300 mg/kg (DFGOT Vol. 4, 1992). Overall, since no tests have been conducted at doses within the range of guidance values, the substance was classified into the "Classification not possible" category.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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