GHS Classification Result

Chemical Name：dipropylamine
CAS：142-84-7

Result：
ID: 20A2200
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Based on its flash point being 7degC (Ullmanns (6th, 2003), HSDB (2008), Hommel (1996)), and initial boiling point being 109.3degC (760 mmHg) (Lide (88th, 2008), HODOC (3rd, 1997), HSDB (2008), Weiss (2nd, 1986), Renzo (1986)), the substance was classified into Category 2.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is documented to be 260degC (Hommel (1996)) and 570degF (299degC) (HSDB (2008), NFPA (13th, 2006)). According to the classification guidelines, a substance with its autoignition point being 70degC or above is classified into the "Not classified" category.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on its rat LD50 of 930 mg/kg (Patty (5th, 2001)), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on its rabbit LD50 values of 925 mg/kg bw (IUCLID (2000)) and 1250 mg/kg bw (HSDB (2008)), the substance was classified into Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Its saturated vapour pressure concentration (conversion value) is 0.46 mg/L. Since its rat LC50 values documented, 4.4 mg/L/4h and > 8.22 mg/L/1h (IUCLID (2000)), are above the saturated vapour pressure concentration, the substance was treated as dusts / mists, and its classification was carried out using mg/L-based concentration criteria. Based on its LC50 values of 4.4 mg/L/4h and > 8.22 mg/L/1h (conversion value: > 2.06 mg/L/4h), the substance was classified into Category 4.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In animal tests, rabbits exposed to the substance for 24 hours showed necrosis (grade 6 on a scale of 1 to 10) (Patty (5th, 2001)), indicating that the substance is corrosive (IUCLID (2000)). In other studies, six rabbit tests and 1 guinea pig test found the substance corrosive. Based on these results, the substance was classified into Category 1. In humans, substance contact with the skin is reported to induce severe irritation (HSDB (2008)).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Rabbits treated with the substance showed irritation (grade 9 on a scale of 1 to 10 (Patty (5th, 2001))). Eight other rabbit tests also found the substance irritating. Based on these results, the substance was classified into Category 1. This substance is known to be a skin corrosive substance, and in humans, contact with eyes is reported to cause severe irritation and edema of the cornea (HSDB (2008)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - It is a possible skin sensitizer (Patty (5th, 2001)), or it was found to be not sensitizing in evaluation using guinea pigs (IUCLID (2000)). In this test, test methods are not provided, however. In addition, since no other test results are obtainable, the substance was classified into the "Classification not possible" category.
5 Germ cell mutagenicity Classification not possible - - - - The substance was classified into the "Classification not possible" category due to lack of in vivo test results that can be used for classification of the substance, and because only negative results have been found in in vitro tests (Ames tests).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system), Category 2 (central nervous system) Danger
Warning 		H370: Causes damage to organs (respiratory system)
H371: May cause damage to organs (central nervous system) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. 		In humans, inhalation of the substance was reported to cause severe coughing and chest pain due to irritation of air passages, and it can cause lung edema, headache, nausea, and faintness (HSDB, 2008). During a 15-minute inhalation exposure (110 mg/L on average) test using rats, all rats were observed with labored breathing and loss of equilibrium 10 to 12 minutes into the exposure (HSDB, 2008). In a mixed diet test using mice (doses: 100-1600 mg/kg), ataxia and convulsions were noted in 1600 mg/kg dose groups (HSDB, 2008). A dermal administration test using rabbits (doses: 0.625-2.50 ml/kg) resulted in observations of effects on internal organs (pale or opaque colorations), which were attributed to corrosivity of the test substance; thus, this study was no considered as grounds for classification. Overall, based on these results, the substance was classified into Category 1 (respiratory system) and Category 2 (central nervous system).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a 2-week mixed diet test using rats (doses: 0-300 mg/kg bw/day), no outward physical or behavioral abnormalities were noted in all subjects, and no toxic symptoms of the kidney or liver were detected in any treated groups (HSDB, 2008). These results indicate that the substance falls under the "Not classified" category. However, since this study was carried out only for 2 weeks, and no other test results are available, the substance was classified into the "Classification not possible" category.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Classification not possible due to lack of data.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information