NITE - Chemical Management Field

GHS Classification Result

Chemical Name：N,N-diethyl-m-toluamide; deet; diethyltoluamide
CAS：134-62-3

Result：


ID:	20A2196
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2008
Reference Manual:	GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	-	-	-	-	Its open cup flash point is documented to be 155degC (Merck 14th, 2006), though no test data using closed cup method is provided. Since the flash point is >= 110degC, the substance was classified into the "Not classified" category regardless of testing methods.
7	Flammable solid	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	-	-	-	-	Its autoignition point is above its flash point of > 110degC (Lange (16th, 2005)), which is above 70degC.
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Since its rat LD50 is above 2000 mg/kg (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in November 2008), the substance was classified into the "Not classified" category using the JIS classification criteria (Category 5 or "Not classified" category in the United Nations classification).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on its rat LD50 of 5000 mg/L and rabbit LD50 of 3180 mg/kg (HSDB, 2003), the substance was classified into the "Not classified" category using the JIS classification criteria (Category 5 in the United Nations classification).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Its rat LC50 (4h) is documented to be >= 4100 mg/m3 (524.8 ppm) (HSDB, 2003). Since the LC50 value is above its saturated vapour pressure concentration (conversion value) of 2.2 ppm, the test was conducted in a dust/mist state. However, since these test results do not provide sufficient information for classification, the substance was classified into the "Classification not possible" category.
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	Since application of this substance produced mild to moderate erythema in rabbits (HSDB, 2003), the substance was classified into Category 2.
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	Since application of this substance to rabbits produced mild to moderate irritation, and these symptoms healed after 5 days (HSDB, 2003), the substance was classified into Category 2B. It is rated as R36/38 in the EU classification (EU-Annex 1, accessed in November 2008), which is equivalent to Category 2 or 3.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Not classified	-	-	-	-	Since in vivo mutagenicity tests (dominant lethal assays using rats or mice) gave negative results (HSDB, 2003), the substance was classified into the "Not classified" category. Regarding in vitro mutagenicity tests, Ames tests gave negative results (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in November 2008), chromosomal aberration tests using CHL cells also gave negative results (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in November 2008), chromosomal aberration tests using CHO cells yielded positive results (HSDB, 2003), and mouse lymphoma assays gave weakly positive results (HSDB, 2003).
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Classification not possible	-	-	-	-	In combined repeated oral dose toxicity study with the reproduction/developmental toxicity tests using rats (OECD TG422, GLP-compliant), no signs of reproduction or developmental toxicity were detected (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in November 2008). However, since the studies do not provide sufficient information on its teratogenicity, the substance was classified into the "Classification not possible" category.
8	Specific target organ toxicity - Single exposure	Category 3 （Narcotic effects）		Warning	H336: May cause drowsiness or dizziness (narcotic effects)	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ...	In acute neurotoxicity tests, narcotic effects were noted in 500 mg/kg dose groups (JMPR, 2002). Thus, the substance was classified into Category 3 (narcotic effects). As additional background information, in single oral administration tests using rats (1000-2000 mg/kg), no abnormalities were detected in treated animals that died during the experiment as well as treated animals that were alive at the end of observational period in pathological examinations (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in November 2008).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	In rat studies, increased urine volume, kidney hypertrophy, and hyaline droplets in the proximal renal tubules were detected for male rats in 60 mg/kg or higher dose groups (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in November 2008). However, since these observed effects may be specific to male rats, the substance was classified into the "Classification not possible" category.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 3	-	-	H402: Harmful to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	Since its 48-hour EC50 = 74 mg/L for crustaceans (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2002), the substance was classified into Category 3.
11	Hazardous to the aquatic environment （Long-term）	Not classified	-	-	-	-	Its classification for acute toxicity is Category 3 and it is not rapidly degradable (non-biodegradable, BOD degradability: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1983). However since its 21-day NOEC = 7.2 mg/L for crustaceans (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2002) and its long-term toxicity is > 1 mg/L, the substance was classified into the "Not classified" category.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）