GHS Classification Result

Chemical Name:2,4,6-trimethyl-1,3,5-trioxan; paraldehyde
CAS:123-63-7

Result:
ID: 20A2189
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Based on its flash point of 36degC (Lide (88th, 2008) p. 16-21), the substance was classified into Category 3. It is rated as UNRTDG 3 III.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 238degC (Lide (88th, 2008)), which is above 70degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen, which is bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - Its documented LD50 values include 1530 mg/kg for rats (RTECS (2006)), 2750 mg/kg for mice (RTECS (2006)), and 3304 mg/kg for rabbits (RTECS (2006)). The value, which represents the highest hazard among the three LD50 values, indicates that the substance falls under Category 4 using the JIS classification criteria. However, since this value was obtained in a List 3 study, the substance was classified into the "Classification not possible" category.
1 Acute toxicity (Dermal) Classification not possible - - - - Its rabbit LD50 is 14.1 ml (14000 mg/kg) (RTECS (2006): Union Carbide Data Sheet), which indicates the classification of the substance into the "Not classified" category; however, since this is a List 3 study, and there are no other test results, the substance was classified into the "Classification not possible" category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Exposing rats to 40000 ppm (21.6 mg/L) of this substance for 4 hours resulted in no mortality (RTECS (2006)). Based on this report, the substance falls under the "Not classified" category; however, since this is a List 3 study, and there are no other test results, the substance was classified into the "Classification not possible" category. Given that its saturated vapour pressure concentration is 198.95 mg/L, the test was presumably conducted using vapour with almost no included mists; thus, evaluation of the substance was carried out using cutoff values for gases.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Rabbit tests found the substance moderately irritating (RTECS (2006)), and its solution is reported to be irritating to the skin and eyes (HSDB (1986)). Thus, the substance was classified into Category 2.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Draize tests using rabbits found the substance severely irritating (RTECS (2006)), and its solution is reported to be irritating to the skin and eyes (HSDB (1986)). Thus, the substance was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Classification is not possible due to lack of in vivo mutagenicity test results and in vitro mutagenicity test results using several indices. Regarding in vitro mutagenicity tests, Ames tests gave positive results (NTP DB (accessed in November 2008)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - Developmental toxicity tests using rats found the substance not teratogenic (Birth Defects (3rd, 2000)). However, since the study did not address the effects of the substance on sexual functions and fertility in parental animals, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system) Danger H370: Causes damage to organs (central nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
At the clinical doses for alcohol dependence medications, miosis, drowsiness, and sleep were noted (PATTY vol. 5 (5th, 2001)). Thus, the substance was classified into Category 1 (central nervous system).
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system, liver, kidney) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, liver, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Digestive disturbance, thirst, emaciation, muscular weakness, mental fatigue and tremors of the hand and tongue/delirium tremens/vivid hallucinations were listed as human chronic symptoms associated with the substance, and continued clinical applications are reported to cause hepatitis and nephrosis (PATTY vol. 5 (5th, 2001). Based on this information, the substance was classified into Category 1 (central nervous system, liver, and kidney).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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