GHS Classification Result

Chemical Name:2-phenoxyethanol
CAS:122-99-6

Result:
ID: 20A2186
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Its flash point is 127degC (closed) (ICSC (J) (2003)), which is above 93degC.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 535degC (Solvents Handbook, Ohmsha Ltd. (1994)), which is above 70degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Since its rat LD50 = 2937 mg/kg for male and 4013 mg/kg for female (GLP-compliant) (SIDS (accessed in November 2008)), the substance was classified into the "Not classified" category using the JIS classification criteria (Category 5 in the United Nations classification).
1 Acute toxicity (Dermal) Not classified - - - - Its rabbit LD50 is represented by six values ranging from 2257 mg/kg to 5548 mg/kg (SIDS (accessed in November 2008)). All values fall under the "Not classified" category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - In skin irritation tests on rabbits using the test substance of technical grade (OECD TG 404), the substance was found to be not irritating (SIDS (accessed in November 2008)). In human studies, of 2736 patients patch-tested, none had signs of irritant reactions. In other human skin irritation tests, there are several reports concluding that the substance is not irritating (SIDS (accessed in November 2008). Thus, it was classified into the "Not classified" category.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
In eye irritation tests using rabbits, Draize scores were reported to be 0 for cornea, 5 for iris, and 8-14 for conjunctiva (SIDS (accessed in November 2008). It is rated as R36 in the EU classification (EU-Annex 1 (accessed in November 2008)). Based on this information, the substance was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - Two different guinea pig maximization tests found the substance not sensitizing (SIDS (accessed in November 2008)). In human studies, patch tests involving 501 patients found the substance not sensitizing (SIDS (accessed in November 2008)). In addition, three different patch tests, with each involving 2736, 3726, or 25 patients, also found the substance not sensitizing (SIDS (accessed in November 2008)). Thus, the substance was classified into the "Not classified" category.
5 Germ cell mutagenicity Not classified - - - - Since both chromosomal aberration tests using bone marrow of rats (in vivo mutagenic tests using somatic cells) and micronucleus tests using erythrocytes of mice that underwent forced oral administration (in vivo mutagenic tests using somatic cells) gave negative results, the substance was classified into the "Not classified" category (SIDS (accessed in November 2008)). Regarding in vitro mutagenicity tests, Ames tests and chromosomal aberration tests using CHO cells gave negative results (NTP DB (1989), SIDS (accessed in November 2008)).
6 Carcinogenicity Not classified - - - - In 104-week carcinogenicity tests using rat or mice that underwent oral administration through drinking water, no increase in incidences of tumors or tumor-related findings were noted in both species and sexes (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare)). In addition, FDA cancer models predict the substance to be non-carcinogenic to both sexes of rats and mice, though the models do not involve real test results related to carcinogenicity (SIDS (accessed in November 2008)). Based on this information, the substance was classified into the "Not classified" category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In two-generation reproduction tests using mice that underwent oral administration, the reduced body weight and increased mortality in neonates were noted at doses that induce general toxicity to parental animals (NTP DB (1989, 1984)). Based on this description, the substance was classified into Category 2. As additional notes, in the test in which rabbits underwent dermal exposure during the organogenic period, no adverse effects of exposure on offspring were detected at doses that induced toxic symptoms in parental animals (SIDS (accessed in November 2008)).
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects) Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
In oral administration tests using rats or mice, temporal comatose, reduction of activity, and ataxia were noted (SIDS (accessed in November 2008)). And since this substance is used as an anesthetic (HSDB (2003)), the substance was classified into Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In 13-week repeated oral administration tests using rats, NOAEL was 80 mg/kg/day and LOAEL was 400 mg/kg/day; kidney inflammation was detected at the dose of 400 mg/kg/day or higher which is above Category 2 guidance values (SIDS (accessed in November 2008)). However, since NOAEL is within the range of Category 2 guidance values, toxic effects that may occur at the upper limit of Category 2 guidance values are unclear. In 90-day repeated dermal exposure tests using rabbits, no adverse effects of treatment were noted in clinical chemical examinations as well as hematologic and histopathological examinations other than sporadic observation of mild erythema on the skin at the dose of 500 mg/kg/day; NOAEL was 500 mg/kg/day (SIDS (accessed in November 2008)). These results indicate that the substance falls under the "Not classified" category for dermal route; however, since effects of the substance through other administration routes are unclear, it was classified into the "Classification not possible" category.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Since its 96-hour LC50 = 344 mg/L for fish (fathead minnow), 48-hour EC50 is > 500 mg/L for crustaceans (Daphnia magna), and 72-hour EbC50 is > 500 mg/L for algae (Scenedesmus) (SIDS, 2006), the substance was classified into the "Not classified" category.
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since it is water soluble (water solubility = 28.9 g/L (SIDS, 2006) and its classification for acute toxicity is "Not classified", the substance was classified into the "Not classified" category.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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