GHS Classification Result

Chemical Name:1,1',1''-nitrilotripropan-2-ol; triisopropanolamine
CAS:122-20-3

Result:
ID: 20A2185
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Its autoignition point is 320degC, which is above 70degC.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - Its boiling point is <= 55degC; due to lack of additional information, classification is not possible.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on its rat LD50 of 4730 mg/kg (PATTY (5th, 2001)), the substance was classified into the "Not classified" category using the JIS classification criteria (Category 5 in the United Nations classification).
1 Acute toxicity (Dermal) Not classified - - - - It is reported that its LD50 for rabbit is 10000 mg/kg (PATTY (5th, 2001)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Based on the report that treatment of rabbits with 85% aqueous solution resulted in the development of erythema, edema, and desquamation (BUA Report No. 148 (1993)), the substance was classified into Category 2.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Application of 85% aqueous solution to the eyes of rabbits resulted in severe conjunctival erythema and chemosis, iridal erythema, and corneal damage; and these symptoms disappeared after 21 days (BUA Report No. 148 (1993)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - In human patch tests in which 98 volunteers were applied with a lotion containing 1.1% concentration of the test substance, no sensitizing reactions were noted. In addition, 25 people were topically applied with a lotion containing 1.1% concentration of the test substance to the back of the hand and the palm five times with each time period lasting for 48 hours. Application was made to the area previously treated with sodium lauryl sulfate. After 10 days, a different area of the hand was applied with the lotion for 48 hours and kept under a seal. No reaction was observed either immediately or 24 hours after application (BUA Report No. 148 (1993)).
5 Germ cell mutagenicity Not classified - - - - The classification is based on the report that in vivo mutagenicity tests using somatic cells (micronucleus tests using mouse bone marrow cells) gave negative results (BUA Report No. 219 (1998)). In vitro mutagenicity tests (Ames tests) also gave negative results (NTP DB (accessed in November 2008)).
6 Carcinogenicity Classification not possible - - - - In a 2-year mixed diet administration test using rats, incidences of tumorigenesis were not different between treated and control animals (BUA Report No. 148 (1993)). However, since the test was conducted using only male rats, and no test results using other animal species are available, classification is not possible.
7 Reproductive toxicity Classification not possible - - - - In oral administration tests conducted during the organogenetic period using pregnant rats, decreased food consumption and body weight gain in maternal animals were observed while signs of fetal toxicity or teratogenic effects were not detected (BUA Report No. 219 (1998)). However, since no test results on reproduction toxicity were available, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects) Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
In oral administration tests using rats, lethargy was observed at the doses of 630 to 10000 mg/kg (BUA Report No. 148 (1993)). These results represent Category 3 (narcotic effects) classification of the substance. In 8-hour inhalation tests using rats, chronic bronchitis was noted although administration dose is not provided. In a dermal administration test using rabbits, no toxic effects were observed at a dose of 5 g/kg (85% solution) (unit conversion: 4250 mg/kg), indicating that the substance falls under the "Not classified" category; however, since this study did not explore other administration routes, the test results cannot be used as grounds for classification. Thus, the substance was classified into Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In 30-day oral administration tests using rats, histopathological changes in the liver, kidney, spleen, and testis were noted at a dose of 0.26 g/kg bw/d (90-day conversion: 86.7 mg/kg bw/d), indicating that the test substance may fall under Category 2; however, details of histopathological changes are not provided. In 2-week oral administration tests using rats, 1) decreased plasma glucose concentrations were noted at doses of 0.3 g/kg bw/d (90-day conversion: 46.7 mg/kg bw/d) or higher for male rats, and 0.6 g/kg bw/d (90-day conversion: 93.3 mg/kg bw/d) or higher for female rats; 2) a statistically significant increase in kidney weights was noted at 0.6 g/kg bw/d or higher for male rats, and 2.0 g/kg bw/d (90-day conversion: 311.1 mg/kg bw/d) for female rats; and 3) suppressed body weight gain in both sexes (also significantly decreased food consumption was noted for female) was detected at 2.0 g/kg bw/d, which was the highest dose tested. However, these observed changes were not considered to be toxic effects. Thus, the substance was classified into the "Classification not possible" category.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since its 72-hour EC50 = 35 mg/L for algae (Scenedesmus) (BUA, 1993), the substance was classified into Category 3.
11 Hazardous to the aquatic environment (Long-term) Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since its classification for acute toxicity is Category 3 and it is not rapidly degradable (non-biodegradable, BOD degradability: 3.4% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1978)), the substance was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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