GHS Classification Result

Chemical Name：benzyl benzoate
CAS：120-51-4

Result：
ID: 20A2182
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Its flash point is 480degC (Chapman (Ver. 16.1, 2008), HSDB (2003), NEPA (13th, 2006)), which is above 70degC.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Among three LD50 values for rats documented 1900 mg/kg, 2800 mg/kg (JECFA Evaluation (2001)), and 1880 mg/kg (PATTY (5th, 2001)), two values fall under Category 4. Thus, the substance was classified into Category 4.
1 Acute toxicity （Dermal） Not classified - - - - Its rat LD50 = 4.46 g/kg (PATTY (5th, 2001)) and rabbit LD50 = 4 g/kg (PATTY (5th, 2001)). Both values fall under the "Not classified" category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - In Draize tests using rabbits, the average scores of the treated animals that received 4-hour applications of this substance for 3 days were 0 to 1.58 (ECETOC TR 66 (1995)). Based on these results, the substance was classified into the "Not classified" category.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Among guinea pig maximization tests conducted, two tests found the substance not sensitizing and one test found it a weak sensitizer (IUCLID (2000)). Human maximization tests also found the substance not sensitizing or induces no positive reaction (IUCLID (2000)). Since these are List 2 studies, the substance was classified into the "Classification not possible" category, instead of the "Not classified" category.
5 Germ cell mutagenicity Classification not possible - - - - Classification is not possible due to lack of in vivo test results and in vitro mutagenicity test results using several indices. Regarding in vitro mutagenicity tests, Ames tests gave negative results (JECFA Evaluation (2001)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In oral exposure conducted during the organogenetic period using rats (PATTY (5th, 2001), Birth Defects (3rd, 2000)) or mice (Birth Defects (3rd, 2000)), no effects on the development of offspring were noted. However, since no study results regarding sexual functions and fertility of parental animals are available, classification is not possible.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Effects of scabicide containing this substance on a 2-month old child include convulsions (PATTY (5th, 2001)). In other study on this substance, results related to blood pressure lowering capabilities were reported (PATTY (5th, 2001)). Since these documents provide only a list of symptoms, not enough information is available. Thus, classification is not possible.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a 90-day dermal administration study using rabbits, atrophy of testis, nephritis, and encephalitis were noted (IUCLID (2000)). In other 90-day dermal administration study using rabbits, atrophy of testis, kidney damage, and increased leukocyte count were detected (IUCLID (2000)). However, since information on exposure dose is unclear in these studies, classification is not possible based on these results.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since its 96-hour LC50 = 4.8 mg/L for crustaceans (a species of Grammaridea) (Aquire, 2008), the substance was classified into Category 2.
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Its classification for acute toxicity is Category 2, it is rapidly degradable (readily biodegradable: 28-day BOD = 90% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1996)), and its potential for bioaccumulation is presumably low (LogPow = 3.97 (PHYSPROP Database, 2008)). Based on these properties of the substance, it was classified into the "Not classified" category.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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