Chemical Name：dichlorprop (ISO); 2-(2,4-dichlorophenoxy) propionic acid
CAS：120-36-5

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Its rat LD50 values documented are 825-1470 mg/kg (IUCLID (2000)), 800 mg/kg (IUCLID (2000)), and 344 mg/kg (HSDB (2008)). All values fall under Category 4. As additional background information, since only the (+) form has physiological activities as herbicides, data on a (+)/(-) racemic mixture are scarce. Thus, when data on a racemic mixture were not available, evaluations were carried out using the (+) form data.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Its rat LD50 of > 4000 mg/kg falls under the "Not classified" category.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Its rat LC50 is reported to be > 0.65 mg/L/4h (HSDB (2008)). Classification is not possible based only on this value. Given that its saturated vapour pressure is 0.2 mg/L, the study was presumably conducted in a dust state.
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	A Draize test using rabbits found the substance irritating (IUCLID (2000)), and another Draize test using rabbits that received a racemic mixture found the substance to be a mild to moderate irritant (HSDB (2008)). In addition to these results, since the substance is rated as R38 in the EU classification, it was classified into Category 2.
3	Serious eye damage/eye irritation	Category 1		Danger	H318: Causes serious eye damage	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician.	A Draize test using rabbits found the substance irritating (IUCLID (2000)), and a rabbit test using a racemic mixture found the substance to be a severe to corrosive irritant (HSDB (2008)). In addition to these results, since the substance is rated as R41 in the EU classification, it was classified into Category 1.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	Both a guinea pig maximization test and a test using a racemic mixture found the substance not a sensitizer (IUCLID (2000), HSDB (2008)). These negative results indicate that the substance falls under the "Not classified" category. However, since these are List 2 studies, it was classified into the "Classification not possible" category.
5	Germ cell mutagenicity	Not classified	-	-	-	-	In sister chromatid exchange assays using Chinese hamsters that received oral administration of a racemic mixture (in vivo genotoxicity tests), positive results were found at toxic doses only, and its genotoxic effect at sub-toxic dose levels could not be determined (HSDB (2008)). Regarding in vitro tests, Ames tests, chromosomal aberration tests using CHL cells, and mutation tests using V79 cells all yielded negative results (HSDB (2008)). No in vivo test results using a macemic mixture are available. However, since chromosomal aberration tests using bone marrow cells of Chinese hamsters that underwent oral administration of the (+) form (in vivo mutagenicity tests using somatic cells) yielded negative results (HSDB (2008)), the substance was classified into the "Not classified" category.
6	Carcinogenicity	Category 2		Warning	H351: Suspected of causing cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Since the substance is rated as Group 2B by the IARC (IARC (1987)), it was classified into Category 2. As additional background information, no increase in incidences of tumorigenesis was noted in either 2-year mixed diet tests using rats, or 18-month mixed diet tests using mice (IUCLID (2000)).
7	Reproductive toxicity	Category 1B		Danger	H360: May damage fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In two-generation reproduction tests using rats (OECD TG 416), no abnormalities were noted in sexual functions and fertility of parental animals or in the offspring (IUCLID (2000)). In oral administration tests conducted during the organogenetic period using rats or rabbits, abnormalities were detected in organs and skeletons of the offspring at non-toxic doses to parental animals (IUCLID (2000)). In addition, in developmental toxicity tests using mice, cleft palate was observed (Birth Defects (3rd, 2000)). Though data on a racemic mixture are not available, using the (+) form data, the substance was classified into Category 1B.
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)		Warning	H371: May cause damage to organs (nervous system)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	Although it is unconfirmed if this study was conducted using a racemic mixture, rats that received oral administration of 250 mg/kg bw or higher doses showed nervous effects (e.g., hypothermia, decreased number of rearing, increased limb splay, retarded righting response, and decreased grip strength) (HSDB (2008)), indicating that the substance falls under Category 1. However, since this is a List 2 study, the substance was classified into Category 2 (nervous system).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	Though this study is not conducted using a racemic mixture, rats that received oral administration for 90 days (doses: 7.2, 36.7, and 193 mg/kg for male; 8.3, 41.4, and 208 mg/kg for female) showed changes in liver weights, biochemical parameters, and hematological parameters at the doses of 193 and 208 mg/kg, which are above Category 2 guidance values; and no effects were seen other than changes in kidney weights at 36.7 and 41.7 mg/kg, which fall under Category 2 guidance doses (HSDB (2008)). In 13-week oral administration tests using rats (doses: 20, 224, and 683 mg/kg for male; 33, 380, and 1043 mg/kg for female), no effects were noted other than changes in eosinophilia in renal tubule cells, liver weights, biochemical parameters, and hematological parameters at the doses of 683 mg/kg and 1043 mg/kg, which are beyond Category guidance doses (HSDB (2008)). In addition, 13-week rat tests found similar changes in the liver and kidney. However, in any of the above studies, toxic effects of the test substance at doses that fall under the range of guidance values are not clear. Thus, the substance was classified into the "Classification not possible" category.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since its 96-hour LC50 = 0.5 mg/L for fish (rainbow trout) (HSDB, 1998), the substance was classified into Category 1.
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since its classification for acute toxicity is Category 1, and it is not rapidly degradable (SRC: BioWin V4.10), the substance was classified into Category 1.