GHS Classification Result

Chemical Name:propene; propylene
CAS:115-07-1

Result:
ID: 20A2180
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Gas (GHS definition)
2 Flammable gases (including chemically unstable gases) Category 1 Danger H220: Extremely flammable gas P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P381: Eliminate all ignition sources if safe to do so.
P403: Store in a well-ventilated place.
The gaseous mixture with air of 13% or lower concentrations is combustible or flammable.
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Classification not possible - - - - No data available.
5 Gases under pressure Low pressure liquefied gas Warning H280: Contains gas under pressure; may explode if heated P410+P403: Protect from sunlight. Store in a well-ventilated place. Since its vapour pressure (1.1566 MPa at 25degC) is above 200 kPa and its critical temperature (91.9degC) is above 65degC, the substance is considered to be a liquid gas (low-pressure liquid gas).
6 Flammable liquids Not applicable - - - - Gas (GHS definition)
7 Flammable solid Not applicable - - - - Gas (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Gas (GHS definition)
9 Pyrophoric liquids Not applicable - - - - Gas (GHS definition)
10 Pyrophoric solids Not applicable - - - - Gas (GHS definition)
11 Self-heating substances and mixtures Not applicable - - - - Gas (GHS definition)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Gas (GHS definition)
13 Oxidizing liquids Not applicable - - - - Gas (GHS definition)
14 Oxidizing solids Not applicable - - - - Gas (GHS definition)
15 Organic peroxides Not applicable - - - - Gas (GHS definition)
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gaseous substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - No data available.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not classified - - - - Based on the information that an inhalation test using rats found the substance not toxic at 50000ppm/4hr (IARC vol. 60 (1994)), it was classified into the "Not classified" category.
1 Acute toxicity (Inhalation: Vapours) Not applicable - - - - Gas (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Not applicable - - - - Gas (GHS definition)
2 Skin corrosion/irritation Classification not possible - - - - Classification not possible due to lack of data.
3 Serious eye damage/eye irritation Classification not possible - - - - Classification not possible due to lack of data.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - Since negative results were obtained in in vivo mutagenicity tests using somatic cells (micronucleus tests using mouse bone marrow (ACGIH (2006))), the substance was classified into "Not classified". Regarding in vitro test results, Ames tests (gas exposure of TA1535) gave positive results (NTP DB (accessed in November 2008)) while mouse lymphoma assays (gas exposure) yielded both positive and negative results (IARC vol.60 (1994), ACGIH (2006)), which makes interpretation of the outcomes difficult.
6 Carcinogenicity Not classified - - - - Since the substance is rated as Group 3 by the IARC, and A4 by the ACGIH, it was classified into the "Not classified" category. As additional background information, carcinogenicity tests using mice or rats that underwent inhalation exposure, an increase in incidences of tumorigenesis was not noted (NTP TR 272 (1985)).
7 Reproductive toxicity Classification not possible - - - - In inhalation exposure tests conducted during the organogenetic period using rats (OECD TG 412/414), signs of teratogenic effects or fetal toxicity were not detected and no abnormalities in parental animals were not noted (ACGIH (2006)). However, since not sufficient information is provided regarding reproductive functions and fertility of female and male rats, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects) Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
Narcotic effects have been noted in the following studies: inhalation tests using rats (PATTY (5th, 2001)), inhalation tests using mice (ACGIH (2006)), inhalation tests on humans (ACGIH (2006), PATTY (5th, 2001)), and inhalation tests using cats (ACGIH (2006)). Since observed narcotic effects disappeared within relatively short period of time after exposure, the substance was classified into Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In four inhalation exposure studies in which rats or mice were exposed to 625 to 10000 ppm of the substance for 2 weeks (90-day correction: 96-1538 ppm) or 14 weeks (NTP TR 272 (1985)), no effects of test substance were noted on general conditions of the treated animals and their body weights as well as in autopsy and histopathological examinations that included observations of nasal cavities. Similarly, effects of the test substance were not noted in inhalation exposure tests in which rats were exposed to 200 to 10000 ppm (90-day correction: 44-2222 ppm) for 20 days (ACGIH (2006)) or mice were exposed to 200 to 5000 ppm for 78 weeks(IARC vol. 60 (1994)). In addition, in inhalation exposure tests using rats or mice that were exposed to 5000 to 10000 ppm for 103 weeks (NTP TR 272 (1985)), no effects of the test substance are mentioned except for changes in nasal cavities such as squamous metaplasia, epithelial hyperplasia, and inflammation seen as non-neoplastic lesions. Changes in nasal cavities were not reported in exposure tests conducted for 2 to 14 weeks. Overall, these eight repeated inhalation exposure studies resulted in no toxic effects related to the test substance have being identified even at exposure doses above the guidance values, indicating that the substance falls under the "Not classified" category (inhalation). However, since no study results exploring other administration routes are available, the substance was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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