GHS Classification Result

Chemical Name：heptanoic acid
CAS：111-14-8

Result：
ID: 20A2175
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Since its flash point of 118degC (closed cup) (Sax (11th, 2004)) is >= 93degC, this substance is not a GHS-classified flammable liquid.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 380degC (Sax (11th, 2004)). According to classification guidelines, a substance with its autoignition point >= 70degC falls under the "Not classified" category.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on its rat LD50 of 7000 mg/kg (JECFA No. 906, accessed in November 2008), the substance was classified into the "Not classified" category.
1 Acute toxicity （Dermal） Not classified - - - - Based on its rabbit LD50 of > 5000 mg/kg (HSDB, 2008), the substance was classified into the "Not classified" category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Its rat LC50 is 4.6 mg/L/4h (HSDB (2008)), which is greater than its saturated vapour pressure concentration (0.07-0.035 mg/L), indicating that the study was conducted in a mist state. This is the only test result available, and the choice between Category 4 and the "Not classified" category cannot be determined. Thus, the substance was classified into the "Classification not possible" category.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Rabbits were exposed to the substance for 4 hours, and as a result, treated subjects, as a whole, were graded 5.6 on a scale of 1 to 8 of the primary irritation index, indicating that the substance is corrosive (Patty 5th, 2001). Based on these results, the substance was classified into Category 1. It is rated as R34 in the EU classification (equivalent to Category 1B or 1C) (EU-Annex 1, accessed in November 2008).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Since it is found to be a skin corrosive substance (based on rabbit skin irritation test (Patty 5th, 2001)), it was classified into Category 1. There are no eye irritation test results available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - No in vivo test data are available, and only negative results have been obtained from in vitro mutagenicity tests (Ames tests) (NTP Database, accessed in November 2008). Thus, the substance was classified into the "Classification not possible" category.
6 Carcinogenicity Classification not possible - - - - In 18-20-month dermal administration tests using mice, skin cancer was not found (Patty (5th, 2001)). In addition, either a mouse skin-painting study or 80-week skin test did not show any evidence of carcinogenicity (HSDB, 2008). Since information obtained was on one species and of dermal administration tests only, the substance was classified into the "Classification not possible" category.
7 Reproductive toxicity Classification not possible - - - - Teratogenicity tests using rats found no signs of developmental toxicity (Patty 5th, 2001), (HSDB (2008)). In addition, reproduction and developmental studies using female rats found no toxic effects either (HSDB, 2008). However, since effects of the substance on male fertility is not explored, the substance was classified into the "Classification not possible" category.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects） Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In oral administration tests using rats (1350-15380 mg/kg bw), symptoms such as hypoactivity, salivation, labored breathing, muscular weakness, and prostration were observed in a dose-dependent fashion, although concentrations that induce these symptoms could not be determined (HSDB, 2008). Based on these results, the substance was classified into Category 3 (narcotic effects). In a hypodermic administration test using rabbits (dose: 0.5 ml, specific gravity correction value: 460 mg/kg), the following changes were observed: discolored abdomen, pigment alteration in the lung, liver, spleen and adrenal, dark red foci in the right kidney and inside walls of the stomach, and vascularization of the intestine. However, since it was a single dose test, we did not use these results as grounds for classification.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In 4-week mixed diet tests using rats (dose: 3400 mg/kg, 90-day correction: 1058 mg/kg), the only symptom noted was body weight reduction (Patty (5th, 2001)). Similarly, in 27-day forced oral administration tests (doses: 0, 875, 1750, and 3500 mg/kg), there were no significant findings that could be related to administration of the test substance at 875 and 1750 mg/kg bw/day (90-day correction: 262.5 and 525 mg/kg, respectively) (HSDB (2008)). These results indicate that the substance falls under the "Not classified" category (oral route), but since there are no test results using other administration routes, the substance was classified into the "Classification not possible" category due to insufficient data available. As additional notes, in 2-week dermal administration tests using rabbits (dose: 500 mg/kg, 25% solution), histopathological examinations found unrevealing results (Patty (5th, 2001)). Thus, these results were not used as grounds for classification.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since its 72-hour ErC50 = 60 mg/L for algae (Pseudokirchneriella subcapitata) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2001), the substance was classified into Category 3.
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Its classification for acute toxicity is Category 3, and its 21-day NOEC = 18 mg/L for crustaceans (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2001). Based on these results, the substance was classified into the "Not classified" category.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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