GHS Classification Result

Chemical Name：1-chlorobutane; butyl chloride
CAS：109-69-3

Result：
ID: 20A2168
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Its flash point is 12degC (Ullmanns (E) (6th, 2003)), which is lower than 23degC, and its initial boiling point is above 35degC, given that its boiling point is 78.5degC (Merck (14th, 2006)). Based on this information, the substance was classified into Category 2.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is above 70degC. Regarding its autoignition points documented in literature, they are scattered widely from 240degC (Lide (88th, 2008)) to 460degC (Ullmanns (E) (6th, 2003))
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not fluorine or oxygen), which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Since its rat LD50 is 2670 mg/kg (SIDS (1997)), the substance was classified into the "Not classified" category using the JIS classification criteria (Category 5 in the United Nations classification).
1 Acute toxicity （Dermal） Not classified - - - - Since its LD50 is > 20 ml/kg or > 17800 mg/kg (SIDS (1997)), the substance was classified into the "Not classified" category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Although its rat LCLo is documented to be 8000 ppm/4h (SIDS (1997)), no other data are available for classification. Given that its saturated vapour concentration is approximately 100000 ppm, tests were presumably conducted in a vaporous state.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Skin irritation tests using rabbits (Open Draize tests and standard Draize tests) found that the substance is moderately to highly irritating (SIDS (1997)). Thus, it was classified into Category 2.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Eye irritation tests using rabbits (Open Draize tests and standard Draize tests) found that the substance is slightly irritating (SIDS (1997)). Thus, it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Skin sensitization tests using guinea pigs (OECD TG 406: Buehler tests) found that the substance is not sensitizing (IUCLID (2000)), indicating that the substance falls under the "Not classified" category. However, since these are List 2 studies, the substance was classified into the "Classification not possible" category.
5 Germ cell mutagenicity Not classified - - - - Six-month chromosomal aberration tests using mouse bone marrow cells (in vivo mutagenicity tests using somatic cells) gave negative results (IUCLID (2000)). Thus, the substance was classified into the "Not classified" category. Regarding in vitro tests, both Ames tests and chromosomal aberration tests using cultured cells of Chinese hamsters gave negative results (NTP DB (accessed in October 2008), Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in October 2008). Mouse lymphoma tests have yielded few positive results (NTP DB (accessed in October 2008)).
6 Carcinogenicity Not classified - - - - In 2-year oral administration tests using rats or mice, survival rates in female and male rats and female mice decreased in the highest dose groups due to mortality caused by convulsions before and after administration. However, incidences of tumorigenesis did not increase in association with the test substance, and thus, no evidence of its carcinogenic effects was found (NTP TR312 (1986)). In EPA's carcinogenicity evaluation, this substance is rated as D (not classifiable as to human carcinogenicity) (IRIS (2005)). Based on these test results and existing classification, the substance was classified into the "Not classified" category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In preliminary reproduction toxicity screening tests using rats that underwent oral exposure (OECD TG), though effects of the exposure on sexual functions and fertility in parental animals were not detected, reduced survival rates of offspring during the nursing period as related to high numbers of neonate mortality in the highest dose groups (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in October 2008). In other oral exposure tests conducted during the gestation period, the offspring were crossbred and subsequently evaluated; as a result, embryo mortality increased in the second generation (NTP TR312 (1986)). It is documented that these adverse effects on the offspring occur only at the doses that cause general toxicity in parental animals such as a decreased body weight, or high doses that show strong toxicity. Based on these observations, the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - To determine the efficacy of this substance as a canine anthelmintic, dogs were orally administered a single dose of the substance; at 0.3 mg/kg (267 mg/kg) or higher doses, lesions of the liver such as fatty infiltration were noted (NTP TR312 (1986)). However, since this study is outdated (conducted in 1932) and was carried out for different purposes, it was not used as grounds for classification. As no other study results are available, classification is not possible.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In reproduction toxicity screening tests using rats that underwent oral administration, no signs of serious toxic effects were noted in males treated with the highest dose of 300 mg/kg/day, other than suppressed body weight gain, reduced food consumption, and salivation being observed (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in October 2008). In addition, in 14-day, 13-week, and 103-week oral administration tests using rats, cases of mortality accompanied with convulsions were detected in the highest dose groups in each study; however, doses of the test substance that fall under the range of guidance values do not show any adverse effects; furthermore, in the 13-week administration study, NOAEL was found to be 120 mg/kg/day (NTP TR312 (1986)). These results indicate that the substance falls under the "Not classified" category (oral route) since administration doses in the range of guidance values did not show adverse effects in treated animals. However, due to lack of test results on other administration routes, the substance was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Since its 96-hour LC50 = 120 mg/L for fish (himedaka), 24-hour EC50 = 380 mg/L for crustaceans (Daphnia magna), and 72-hour EbC50 is > 1000 mg/L for algae (SIDS, 2005), the substance was classified into "Not classified".
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since it is water soluble (water solubility = 370 mg/L (SIDS, 2005), and its classification for acute toxicity is "Not classified", the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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