GHS Classification Result

Chemical Name:2-methylpyridine; 2-picoline
CAS:109-06-8

Result:
ID: 20A2166
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Its flash point (28degC) is >=23degC and <= 60degC (IMDG (2006)).
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 535degC (Hommel (1996)), which is above 70degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Its documented rat LD50 values include 400-1600 mg/kg (PATTY (5th, 2001)) and 790 mg/kg bw (IUCLID (2000)), which fall under Category 4. The EU Risk Phrase for the substance is R22.
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Its rabbit LD50 of 410 mg/kg (PATTY (5th, 2001)) falls under Category 3. The EU Risk Phrase for the substance is R21.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Since its rat LC50 is 13 mg/L/4h (3390 ppm) (IUCLID (2000)), and its EU Risk Phrase is R20 (EU-Annex 1 (accessed in October 2008)), the substance was classified into Category 4. Given that its saturated vapour pressure is 56.15 mg/L, the test was carried out in a vapour state with almost no included mists.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
In dermal route tests using six rabbits, dried skin was observed after 24 hours and encrustation was observed after 72 hours in all six treated animals, causing necrosis and thickening of the treated skin areas by strong irritation and corrosive effects. In addition, according to the test report, 5 of 6 treated animals showed signs of corrosive effects after 4-hour exposure (IUCLID (2000)). Thus, the substance was classified into Category 1.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
Rabbit tests found that the substance is corrosive (IUCLID (2000)). In other rabbit tests, keratitis and symptoms associated with corneal epithelial tissues and fibrillary edema were observed, which were graded 8 (HSDB (2002)). In addition, since it represents Category 1 for skin corrosion / irritation, the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Guinea pig maximization tests found that the substance is not sensitizing (IUCLID (2000)), indicating it represents the "Not classified" category. However, because these are List 2 studies and there are no other test results available, the substance was classified into the "Classification not possible" category.
5 Germ cell mutagenicity Classification not possible - - - - Classification is not possible due to lack of in vivo test results and in vitro mutagenicity test results using several indices. As additional notes, Ames tests (in vitro mutagenicity tests) gave negative results (IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In oral route tests using rats, since structure and composition of the liver and the structure and growth pattern of the skin were disrupted in the offspring (IUCLID (2000)), the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system) Warning H371: May cause damage to organs (central nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
In oral administration tests using mice, depression of the central nervous system and sleepiness were noted (doses not given) (IUCLID (2000)). In addition, in oral administration tests via gavage using rats that were treated with 550, 790, or 950 mg/kg, of 6 of 10 rats survived in the group given 950 mg/kg, which falls under Category 2 guidance doses, 2 rats showed signs of encephalomalacia (HSDB (2002)). Furthermore, in inhalation tests using rats (4-hour exposure; doses: 5.4, 11.4, 12.5, and 21.9 mg/L), signs of ataxia and narcosis were observed at 12.5 mg/L, which falls under Category 2 guidance values (IUCLID (2000)). Based on these results, the substance was classified into Category 2 (central nervous system).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In 28-day oral administration tests using rats, no serious toxic effects of administration were noted other than a slight increase in liver weight at the highest dose of 150 mg/kg/day (90-day correction value: approximately 47 mg/kg/day) (IUCLID (2000)). Similarly, in several 6-month inhalation exposure tests using rats (IUCLID (2000), PATTY (5th, 2001), HSDB (2002)), no effects of the test substance exposure were detected except for an increased liver weight seen in few animals. Although these tests did not detect any effects of the substance, test doses were set so low that the highest doses used were below the upper limit of the range of Category 2 guidance values. Due to low doses tested, classification is not possible based on these tests.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Since its 96-hour LC50 = 897 mg/L for fish (fathead minnow) (ECOTOX, 2008), the substance was classified into the "Not classified" category.
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since it is water soluble (water solubility = 1000000 mg/L (SRC, 2005), and its classification for acute toxicity is the "Not classified" category, the substance was categorized into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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