GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：propylene carbonate
CAS：108-32-7
Result：
| ID: | 20A2164 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2008 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （Sep, 2008） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Not classified | - | - | - | - | Its flash point is 116degC (IUCLID (2000)), which is above 93degC. |
| 7 | Flammable solid | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Its autoignition point is 435degC (IUCLID (2000)), which is above 70degC. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Its rat LD50 is >= 29000 mg/kg in all three tests documented (IUCLID (2000)). |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | The classification is based on the description that the LD50 for rabbits is > 20000 mg/kg (IUCLID (2000)). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | It has been reported in rat tests that no mortality related to exposure to this substance is detected (PATTY (5th, 2001)); however, exposure concentrations were not provided and classification is not possible based on this report. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Not classified | - | - | - | - | The classification is based on descriptions that the substance was found to be a slight irritant in rabbit tests (PATTY (5th, 2001)) and it caused no irritation in other rabbit tests (OECD Guidelines 404) (IUCLID (2000)). |
| 3 | Serious eye damage/eye irritation | Category 2A |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
The substance was found to be a moderate irritant in rabbit tests (PATTY (5th, 2001). In other rabbit tests (OECD Guidelines 405), its scores for corneal clouding and conjunctival erythema were 1.72 and 2.67, respectively, leading to the conclusion that the substance is irritating (IUCLID (2000)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | Human patch tests found that the substance is not sensitizing (IUCLID (2000)); however, test details are not provided and classification is not possible based on this report. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Classification is not possible due to lack of in vivo test data. Regarding in vitro tests, Ames tests and chromosomal aberration tests both yielded negative results (IUCLID (2000)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No data available. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | In 21-day inhalation exposure tests using guinea pigs or dogs, no effects of exposure were noted at 2.8 mg/L/6h (90-day conversion value: 0.65 mg/L/6h), which falls under Category 2 guidance values (IUCLID (2000)). In 21-day inhalation exposure tests using rats, rough breathing and diarrhea were noted at 2.8 mg/L/6h (90-day conversion value: 0.65 mg/L/6h), which falls under Category 2 guidance values (IUCLID (2000)). In addition, in 1-month dermal administration tests using rats, hyperkeratosis of the skin and an increase in basal cells were detected; however, test details such as administration doses are not provided (IUCLID (2000)). Since effects of the substance in the range of guidance doses are not clear, it was classified into the "Classification not possible" category. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Not classified | - | - | - | - | Based on its 96-hour LC50 of > 1000 mg/L for fish (carp), 48-hour EC50 of > 1000 mg/L for crustaceans (Daphnia magna), and 72-hour EC50 of > 900 mg/L for algae (Scenedesmus subspicatus) (IUCLID, 2000), the substance was classified into the "Not classified" category. |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Since it is rapidly degradable (28-day BOD degradability = 79%, GC degradability = 89% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1993)), and its classification for acute toxicity is the "Not classified" category, the substance was classified into "Not classified". |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |