GHS Classification Result

Chemical Name:butyric acid
CAS:107-92-6

Result:
ID: 20A2163
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Its flash point is 77degC (Merck (14th, 2006)), which is between 60 and 93degC.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 443degC (HSDB (2006)), which is above 70degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Since all three documented LD50 values for rats (2000, 2940, and 8790 mg/kg) are >= 2000mg/kg (PATTY (5th, 2001)), the substance was classified into the "Not classified" category using JIS classification criteria (Category 5 in the United Nations GHS classification).
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Of two rabbit LD50 values documented, 530 mg/kg (PATTY (5th, 2001), which represents a higher harzard of the two, was chosen as grounds for the classification of the substance into Category 3.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Inhalation exposure to the saturated vapour of the substance (2170 ppm at 25degC) for 8 hours (4-hour conversion: 3069 ppm) did not cause mortality in rats (PATTY (5th, 2001)). However, since the LC50 value is not provided in this document, a category for this substance cannot be determined. Thus, classification is not possible.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
In List 1 data (PATTY (5th, 2001)), the substance is documented to be a severe irritant in rabbit tests, and in List 2 data (IUCLID (2000)), it is reported to be corrosive in rabbit tests (OECD Guidelines 404). In addition, it is rated as R34 in the EU classification.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
The substance is documented to cause severe corneal burns in rabbit tests (PATTY (5th, 2001)), and it is classified into Category 1 for skin corrosion and irritation.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Although negative results have been documented in in vitro tests (Ames tests and chromosomal aberration tests) (PATTY (5th, 2001)), there are no in vivo tests documented. As such, classification is not possible due to insufficient data available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In oral administration tests conducted during the organogenic period using pregnant rats, mortality was high and body weight gain was greatly inhibited in maternal animals while no effects of administration on offspring were detected (PATTY (5th, 2001)). Since no reports on its reproductive toxicity are obtainable, due to insufficient data available, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 2 (lung) Warning H371: May cause damage to organs (lung) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
In inhalation exposure (aerosol) tests using rabbits, signs of bronchitis and emphysema were noted at the dose of 40 mg/L/1.5h (4-hour conversion value: 15 mg/L/4h) (PATTY (5th, 2001)), which is out of the Category 2 guidance value range. In other inhalation tests using rabbits, congestion, edema, atelectasis, and emphysema of the lungs were detected at the dose of 0.4 mg/L/1.4h (4-hour conversion value: 0.24 mg/L), which falls under Category 1 guidance doses (IUCLID (2000)). However, since the results were obtained using List 2 datasets, the substance was classified into Category 2 (lung).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In 35-week mixed diet administration tests using rats, papillomatosis and hyperkeratosis of gastric tissues were noted in four rats (PATTY (5th, 2001)). However, details of the tests are not provided, and thus, classification is not possible due to insufficient data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since its 48-hour LC50 = 61 mg/L for crustaceans (Daphnia magna) (HSDB, 2006), the substance was classified into Category 3.
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Its classification for acute toxicity is Category 3; however, since it is rapidly degradable (BOD degradability = 72% (HSDB, 2006)) as its bioaccumulation potential is presumably low (logPow = 0.79 (PHYSPROP Database, 2008)), the substance was classified into the "Not classified" category.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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