NITE - Chemical Management Field

GHS Classification Result

Chemical Name：but-1-ene
CAS：106-98-9

Result：


ID:	20A2161
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2008
Reference Manual:	GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	Gas (GHS definition)
2	Flammable gases （including chemically unstable gases）	Category 1		Danger	H220: Extremely flammable gas	P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking. P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely. P381: Eliminate all ignition sources if safe to do so. P403: Store in a well-ventilated place.	At standard pressure of 101.3 kPa at 20degC, the lower limit of explosive range of the gaseous mixture with air is 1.6% (Ullmanns (E) (6th, 2003)), which is below 13%. The UNRTDG has classified the substance into Division 2.1.
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not classified	-	-	-	-	It is a flammable gas.
5	Gases under pressure	Low pressure liquefied gas		Warning	H280: Contains gas under pressure; may explode if heated	P410+P403: Protect from sunlight. Store in a well-ventilated place.	Its critical temperature is 146.45degC (Ullmanns (E) (6th, 2003)), which is above 65degC.
6	Flammable liquids	Not applicable	-	-	-	-	Gas (GHS definition)
7	Flammable solid	Not applicable	-	-	-	-	Gas (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	Gas (GHS definition)
9	Pyrophoric liquids	Not applicable	-	-	-	-	Gas (GHS definition)
10	Pyrophoric solids	Not applicable	-	-	-	-	Gas (GHS definition)
11	Self-heating substances and mixtures	Not applicable	-	-	-	-	Gas (GHS definition)
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	Gas (GHS definition)
13	Oxidizing liquids	Not applicable	-	-	-	-	Gas (GHS definition)
14	Oxidizing solids	Not applicable	-	-	-	-	Gas (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Gas (GHS definition)
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to gaseous substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Gases）	Classification not possible	-	-	-	-	Although inhalation exposure tests using mice have been conducted, the period of exposure was not provided and it is questionable whether observational period after exposure was sufficient. Therefore, classification is not possible.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Not applicable	-	-	-	-	Gas (GHS definition)
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available.
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available. Although the substance is reported to cause mild irritation (PATTY (5th, 2001)), this conclusion cannot be verified with detailed study information.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Classification is not possible due to lack of in vivo data. Ames tests (PATTY (5th, 2001)) and micronucleus tests using mouse bone marrow cells (SIDS (2009)) both gave negative results.
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Classification not possible	-	-	-	-	In combined repeated oral dose toxicity study with the reproduction/developmental toxicity tests using rats (OECD TG 422), no effects of the administration on sexual functions, fertility, and delivery in parental animals as well as no effects on offspring were noted (TEXAS COMMISSION ON ENVIRONMENTAL QUALITY Development Support Document Final, April 15, 2008). NOAEL is reported to be 8000 ppm (SIDS (J) (accessed in October 2008)). However, since available data on the effects on development of offspring and teratogenicity are insufficient, classification is not possible.
8	Specific target organ toxicity - Single exposure	Category 3 （Narcotic effects）		Warning	H336: May cause drowsiness or dizziness (narcotic effects)	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ...	As a result of inhalation exposure of 15 to 30% concentration 1-butene, deep anesthesia was induced in mice (PATTY (5th, 2001)). In addition, surgical anesthesia in mice was obtained with 22.7% 1-butene in the atmosphere (IUCLID (2000)). Based on these reports, the substance was classified into Category 3 (narcotic effects).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	In combined repeated dose toxicity study with the reproduction/developmental toxicity screening tests using rats (OECD TG 422: GLP-compliant), the effects of the test substance (gas) exposure was not detected at all (TEXAS COMMISSION ON ENVIRONMENTAL QUALITY Development Support Document Final, April 15, 2008). NOAEL is reported to be higher than 8000 ppm, which is the highest concentration tested (SIDS (J) (2008)). The tests, though they are screening tests focusing only on rats, are reliable and valid tests, and found that NOAEL is greatly higher than the cutoff value (250 ppm) of Category 2 guidance values (at least 10 times higher), indicating that the substance falls under the "Not classified" category (inhalation). However, since no data on other administration routes are available, the substance was classified into the "Classification not possible" category.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Classification not possible	-	-	-	-	No data available.
11	Hazardous to the aquatic environment （Long-term）	Classification not possible	-	-	-	-	No data available.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）