GHS Classification Result

Chemical Name：2-(morpholinothio)benzothiazole
CAS：102-77-2

Result：
ID: 20A2157
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Classification not possible - - - - No data available.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Of four rat LD50 values documented (> 7940 mg/kg, > 5000 mg/kg, > 10000 mg/kg, and 1980 mg/kg (IUCLID (2000)), three values fall under the "Not classified" category and one value falls under Category 4. Giving precedence to the more represented category of two, the substance was classified into "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - Since its rabbit LD50 is > 7940 mg/kg (IUCLID (2000)), the substance was classified into the "Not classified" category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - Draize tests using rabbits found that a 24-hour application of the substance is not irritating (IUCLID (2000)). Other skin irritation tests using rabbits also discovered that the substance is not irritating (IUCLID (2000)). Based on these results, the substance was classified into the "Not classified" category. As additional information, skin irritation tests using guinea pigs found that the substance produced irritant reactions (IUCLID (2000)).
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Draize tests using rabbits found that a 24-hour application of the substance is slightly irritating. Other rabbit tests also revealed that the substance is slightly to moderately irritating. Based on these results, the substance was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Positive results have been obtained in both human patch tests (IUCLID (2000)) and guinea pig tests adopting Buehler's method (IUCLID (2000), HSDB (2003)). Thus, the substance was classified into Category 1.
5 Germ cell mutagenicity Classification not possible - - - - Dominant lethal assays using rats (in vivo heritable mutagenicity tests using germ cells) found positive results (IUCLID (2000)); however, because only one dose was used in the assays and insufficient test information was provided, evaluation of the results was difficult. Regarding in vitro mutagenicity tests, Ames tests (IUCLID (2000)) and chromosomal aberration tests using CHO cells (HSDB (2003)) yielded negative results while mouse lymphoma assays gave positive results (IUCLID (2000)), and in mutation tests using CHO cells, both negative and positive results have been obtained (IUCLID (2000), HSDB (2003)). Overall, with an expert judgement, we could not validate the positive results obtained in in vivo tests (dominant lethal assays), and we could not reach definitive conclusions based on negative and positive results found in in-vitro tests. Thus, the substance was classified into the "Classification not possible" category.
6 Carcinogenicity Not classified - - - - No signs of carcinogenicity were detected in the following tests: 2-year oral administration (mixed diet) tests using rats, 79-week forced oral administration tests using mice, 21-month oral administration (mixed diet) tests, and 18-month oral administration tests (IUCLID (2000)). Thus, the substance was classified into the "Not classified" category. In addition, no indication of tumorigenicity was detected in mice that received subcutaneous administration (IUCLID (2000)).
7 Reproductive toxicity Not classified - - - - In reproduction tests using female and male rats, no visible signs of poisoning, such as changes in the estrous cycle, delay in conceptions, and increased total embryonic mortality, were detected (IUCLID (2000)). In addition, in several oral administration tests conducted during the organogenetic period using rats, no adverse effects of administration such as incidences of fetal malformation and a decreased number of embryos due to post-implantation loss, were detected (IUCLID (2000)). Based on these results, the substance was classified into the "Not classified" category.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Not classified - - - - No changes due to administration of the substance were detected, other than changes in organ weight, at the following doses in the following tests: an application of 1000 mg/kg in 4-week oral administration tests using rats (dose: 100, 200, 500, and 1000 mg/kg), an application of 1125 mg/kg in 3-month oral administration (mixed diet) tests (dose: 18, 69, 282, and 1125 mg/kg), an application of 1500 mg/kg in 21-month oral administration (mixed diet) tests (dose: 15, 150, and 1500 mg/kg), and an application of 125 and 250 mg/kg in 56-day forced oral administration tests (dose: 125, 250, and 500 mg/kg) (IUCLID (2000)). Since no effects of administration were detected within the range of guidance doses, the substance was classified into the "Not classified" category. Additionally, in 4-week inhalation exposure tests (6 hours/day and 5 days/week, dose: 0.0044, 0.0098, and 0.0102 mg/L), no pathological changes were observed, other than slight body weight reductions and changes in organ weights and biochemical values, at the highest dose tested (IUCLID (2000)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since its 96-hour LC50 = 1.3 mg/L for fish (Oncorhynchus mykiss) (IUCLID, 2004), the substance was classified into Category 2.
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its classification for acute toxicity is Category 2, and it is not rapidly degradable (SRC: BioWin V4.10), the substance was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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