GHS Classification Result

Chemical Name:ethyl methacrylate
CAS:97-63-2

Result:
ID: 20A2152
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Its flash point is 15degC (Gangolli (2nd, 1999)), which is < 23degC. Its initial boiling point is either 118degC (Ullmanns (E) (6th, 2003, vol. 28)), 119-120degC (Chapman ver. 16.1 (2008)), or 117degC (HODOC (3rd, 1997)), which is > 35degC. Thus, the substance was classified into Category 2.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Type G - - - - An acrylic group is considered to be an unsaturated bond. Since transportation goods containing a self-polymerization inhibitor (hydroquinone) (UN No. 2277) is categorized into the United Nations Class 3, the substance is not dangerous in terms of its self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 450degC (ICSC (2003)), which is above 70degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Its publicized rat LD50 values, 12.7-18.14 g/kg (PATTY (5th, 2001)) and 14.8 g/kg bw (PATTY (5th, 2001)), both fall under the "Not classified" category.
1 Acute toxicity (Dermal) Not classified - - - - Its rabbit LD50 value, > 9.1 g/kg bw (PATTY (5th, 2001), HSDB (2002)), falls under the "Not classified" category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Since its rat LC50 is 8300 ppm/4h (HSDB (2002)), the substance was classified into Category 4. As this study was conducted under the condition in which the LD50 is <= 90% of its saturated vapour pressure, evaluation was carried out using criteria for gases.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - There is a description of human cases in which the substance causes allergic contact dermatitis (PATTY (5th, 2001)). However, classification is not possible based on this information alone.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Guinea pig maximization tests gave positive results (DFGOT vol. 16 (2001)). In addition, patch tests found positive results in dermatitis patients (some of them developed occupation-related dermatitis) and people who have been exposed to ethyl methacrylate or those who are suspected to have been exposed to it (DFGOT vol. 16 (2001)). Based on this information, the substance was classified into Category 1.
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In rats that underwent intraperitoneal administration, signs of fetal toxicity and teratogenicity were noted (PATTY (5th, 2001), Birth Defects (3rd, 2000)). On the other hand, there is a description that inhalation exposure did not cause embryonic lethality or teratogenic efffects (SIDS (J) accessed in September 2008). Some results were based on intraperitoneal administration tests; in addition, only limited information is available and we cannot verify the consistency of test results. Thus, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation) Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
In oral administration tests using rats, respiratory system disorder was noted at administrations of 12.7-18.14 g/kg, which fall under the "Not classified" category guidance values; and in inhalation tests using rats, respiratory tract irritation was induced (PATTY (5th, 2001)). In addition, it is documented that vapour of the substance may cause irritation to mucous membrane in humans and exposure to monomers of the substance may cause central nervous system disorder (PATTY (5th, 2001)). It is rated as R37 in the EU classification. Based on these pieces of information, the substance was classified into Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In 60-day oral administration tests using rats, degeneration of the brain and spinal cord was noted at 6570 and 600 mg/kg, which are above Category 2 guidance doses (RTECS (2008)). However, since these results were obtained using List 3 datasets, and due to insufficient data available, classification is not possible.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since its 21-day NOEC = 18 mg/L for crustaceans (Daphnia magna) (Acquire 2008), the substance was classified into the "Not classified" category.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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