GHS Classification Result

Chemical Name:symclosene; trichloroisocyanuric acid; trichloro-1,3,5-triazinetrion
CAS:87-90-1

Result:
ID: 20A2145
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Classified into UNRTDG 5.1.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Not classified - - - - Nonflammable (ICSC (J) (2007)).
8 Self-reactive substances and mixtures Type G - - - - Classified into UNRTDG 5.1.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Nonflammable (ICSC (J) (2007)).
11 Self-heating substances and mixtures Not classified - - - - Nonflammable (ICSC (J) (2007)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Category 2 Danger H272: May intensity fire; oxidizer P370+P378: In case of fire: Use ... for extinction.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P221: Take any precaution to avoid mixing with combustibles/...
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Classified into UNRTDG 5.1 II.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Its rat LD50 values are 406 mg/kg (HSDB (2008)), 490 mg/kg (IUCLID (2000)), and 750 mg/kg (HSDB (2008)), which are equivalent to the guidance value of Category 4. As relevant information, it is reported that its rat LD50 values are 1000 mg/kg, 1060 mg/kg (male), and 1010 mg/kg (female) (the above, IUCLID (2000)). However, since the original literature was not described, the data were not used as the evidence for classification.
1 Acute toxicity (Dermal) Not classified - - - - Its rabbit LD50 > 2000 mg/kg (IUCLID (2000)), rabbit LD50 = 20000 mg/kg (IUCLID (2000)), and rabbit LDLo = 5010 mg/kg (RTECS (2003)) are equivalent to the guidance value of "Not classified" in JIS classification (also "Not classified" in UN classification).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Not classified - - - - Its rat LC50 > 50 mg/L/1h (> 12.5 mg/L/4h) (IUCLID (2000)), which is equivalent to the guidance value of "Not classified". As relevant information, its vapour pressure is 1.25E-007 mmHg (25degC, estimated) (conversion, 0.0000166625 Pa (25degC, estimated)) (Howard (1997), SRC (accessed in September 2008)). The saturated vapour pressure concentration obtained by calculation using the vapour pressure was 0.01558 mg/L. Therefore, the substance was considered as dust.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
It is documented that in a test using rabbits, the substance was moderately irritating (IUCLID (2000)), and in a standard Draize test using rabbits, its irritation was moderate (RTECS (2003)). Therefore, the substance was classified into Category 2.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
It is reported that as findings of Draize tests using rabbits, the substance was highly corrosive (IUCLID (2000)), its irritation was severe (RTECS (2003)). Therefore, the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Since there is no available in vivo test data using the substance, classification is not possible. As for in vitro mutagenicity tests, an Ames test (IUCLID (2000)) and a mouse lymphoma assay (IUCLID (2000)) indicated negative results. As relevant information, a chromosomal aberration test using rat bone marrow cells with oral administration of monosodium cyanurate, a metabolite, by gavage (in vivo mutagenicity tests using somatic cells) indicated negative results (IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - - Since there is no available test data using the substance, it was classified into "Classification not possible". As relevant information, a rat test for 24 months and a mouse test for 104 weeks?both with drinking water administration including monosodium cyanurate, a metabolite?did not show increased development of tumors (IUCLID (2000)).
7 Reproductive toxicity Classification not possible - - - - Since there is no available test data using the substance, it was classified into "Classification not possible". As relevant information, in a three-generation reproductive toxicity test with drinking water administration including monosodium cyanurate, a metabolite, there was no effects on parental fertility and sexual functions, or development of fetuses, and in developmental toxicity tests using rats and rabbits with oral administration during the organogenetic period, no effects on fetal toxicity and teratogenicity were observed (IUCLID (2000)).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Since there is no available test data on the substance, classification is not possible. As relevant information, it is reported that in a repeated exposure test for 13 weeks using rats and mice and monosodium cyanurate, a metabolite, in rats, bladder calculi were noted (IUCLID (2000)) and in mice, hyperplasia of the urinary bladder epithelium was observed (IUCLID (2000)). It is described that as chlorinated cyanuric acid metabolizes rapidly to the stable dechlorinated compound in mammalian systems, the test articles used in the study were cyanuric acid and monosodium cyanurate (IUCLID (2000)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Based on its 96h-LC50 = 0.08 mg/L for fish (rainbow trout) (ECOTOX, 2008), the substance was classified into Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its preexisting classification for acute toxicity is Category 1, and it is not rapidly biodegradable (non-biodegradable; BOD degradability, 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1978)), the substance was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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