GHS Classification Result

Chemical Name:cyclohexane-1,2-dicarboxylic anhydride
CAS:85-42-7

Result:
ID: 20A2143
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Its autoignition point is 395degC (IUCLID (2000)). Based on the classification guidance, if the autoignition point is 70degC or higher, the substance is classified into "Not classified".
11 Self-heating substances and mixtures Classification not possible - - - - Its melting point is 32degC (Lide (88th, 2008), HODOC (3rd, 1994)). Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on its rat LD50 = 2700 - 2800 mg/kg (ACGIH (2004)), the substance was classified into "Not classified" in JIS classification (Category 5 in UN classification).
1 Acute toxicity (Dermal) Not classified - - - - Based on the results that acute dermal toxicity was tested on rabbits at a dose of 2000 mg/kg bw, and no rabbits died (ACGIH (2004)), the substance was classified into "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Not classified - - - - Since its rat LC50 value > 1100 mg/m3/4h (ACGIH (2004)) is above its saturated vapour pressure concentration of 0.056 mg/L, the substance is considered as "mist." The substance is classified into "Not classified" in JIS classification, Category 5 or "Not classified" in UN classification.
2 Skin corrosion/irritation Not classified - - - - In humans, the substance caused skin, eye, nose and throat irritation (IUCLID (2000)). The substance was found to be irritating according to the Draize test on rabbits (ACGIH (2004)). Since the original literature of the test using rabbits documented that the substance was slightly irritating and its score was 0.92, it was classified into "Not classified" (Category 3 in UN classification).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
There is a case report of a worker who was diagnosed with occupational conjunctivitis from airborne HHPA exposure (ACGIH (2004)). The substance was classified as corrosive following a Draize test with rabbits with and without irrigation of the eyes, and irrigation after 4 seconds resulted in severe but reversible irritation (ACGIH (2004)). Based on the description of "corrosive" in the rabbit test, the substance was classified into Category 1. It is rated R42 (equivalent to Category 1) in the EU classification (EU-Annex I (accessed in September 2008)).
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ...
In a number of reports, workers who treat this substance developed IgE-, IgG-mediated hypersensitivity (such as rhinitis, asthma), and in 13 workers with complaint of rhinitis, asthma, and others and who were exposed to HHPA or MTHPA, 8 workers were HHPA positive via the skin-prick test (ACGIH (2004)). Since it is rated R42/43 (equivalent to Category 1) in the EU classification (EU-Annex I (accessed in September 2008)), Sa mark by DFG (MAK/BAT (2007)), SEN by ACGIH (ACGIH-TLV (2007)), the substance was classified into Category 1.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Exposure to HHPA can cause contact urticaria according to a case report where a worker was exposed only through airborne means (ACGIH (2004)). In a guinea pig maximization test (OECD TG 406, non-GLP), 19 of 20 animals showed positive response, and its result was sensitizing (IUCLID (2000)). It is rated R42/43 (equivalent to Category 1) in the EU classification (EU-Annex I (accessed in September 2008)). Based on the above results, the substance was classified into Category 1.
5 Germ cell mutagenicity Classification not possible - - - - As for in vivo tests, there is no data available, and as for in vitro mutagenicity tests, the available result is solely that using standard Ames test procedures, the substance was negative (ACGIH (2004)). Therefore, the substance was classified into "Classification not possible".
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects) Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since, in an oral administration test by gavage, it is reported that sedation, ataxia, and dizziness were observed (IUCLID (2000)), the substance was classified into Category 3 (narcotic effects). It is documented that in humans, general symptoms like anemia, headache, and dizziness were seen (IUCLID (2000)).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since its 72h-EC50 = 95.6 mg/L for algae (Scenedesmus subspicatus) (IUCLID (2000)), the substance was classified into Category 3.
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Its preexisting classification for acute toxicity is Category 3. However, its 72h-EC10 = 45.4 mg/L for algae (Scenedesmus subspicatus) from a long-term toxicity test (IUCLID (2000)). Therefore, the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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