GHS Classification Result

Chemical Name:trilead bis(orthophosphate)
CAS:7446-27-7

Result:
ID: 20A2138
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Not classified - - - - Nonflammable (HSFS (2007)).
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Nonflammable (HSFS (2007)).
11 Self-heating substances and mixtures Not classified - - - - Nonflammable (HSFS (2007)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - It is documented that the substance is water soluble (0.000014 g/100 cm3 water, 20degC) and stable to water (HSDB (2005)).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available.
15 Organic peroxides Not applicable - - - - Inorganic substance
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - We could not find data of the substance. Referring to adverse effects of inorganic lead compounds on health is recommended.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - DFGOT 17 (2002) stated that, in the section of 4 Effects in Man, there are no data available for the local effects of lead or inorganic lead compounds on skin and mucous membranes.
3 Serious eye damage/eye irritation Classification not possible - - - - DFGOT 17 (2002) stated that, in the section of 4 Effects in Man, there are no data available for the local effects of lead or inorganic lead compounds on skin and mucous membranes.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since it is reported that rats received subcutaneous injections during treatment periods of up to 16 months, 19 of 29 rats that survived developed renal tumors (IARC vol.1, 1972), and the substance was administered to rats by subcutaneous injections for 18 months, and renal adenomas developed in rats (HSDB (2005)), the substance was classified into Category 2. As relevant information, in IARC, lead acetate is classified into 2B, which is equivalent to Category 2.
7 Reproductive toxicity Category 1A Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
We could not find any information of the substance. However, since it is known that, in humans, inorganic lead compounds are developmental neurotoxic substances and reproductive toxicants, based on expert judgment, the substance was classified into Category 1A. The substance is rated R61, is classified into Category 1 in the EU classification (EU-Annex I (accessed in August 2008)).
8 Specific target organ toxicity - Single exposure Category 1 (kidney, digestive system, cranial nervous system) Danger H370: Causes damage to organs (kidney, digestive system, cranial nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
A classification of this substance was conducted based on the effects of inorganic lead compounds. It is reported that in persons whose blood lead level was above 1250 or 1500 microg/L after acute lead poisoning, functional disorders of the epithelium of the proximal renal tubules were detected (DFGOT 17 (2002)), on the other hand, it is also reported that in 31 patients with lead poisoning (blood lead levels 400 to 1750 microg/L), no clinical signs of kidney damage were seen (DFGOT 17 (2002)). Colic is the initial symptom of acute lead poisoning with high doses, and the symptoms are such as abdominal pain, constipation, cramp, nausea, vomiting, anorexia, and weight loss. It is reported that at doses causing severe gastrointestinal tract disturbance, the substance caused encephalopathy (ATSDR, 2007). Based on the above, the substance was classified into Category 1 (kidney, digestive organs, cerebral nervous system).
9 Specific target organ toxicity - Repeated exposure Category 1 (blood system, kidney, nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (blood system, kidney, nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
As for this substance, classification was conducted based on the effects of inorganic lead compounds. DFGOT 17 (2002) described as for the kidneys, blood pressure, the thyroid gland, and nervous systems, in the section of 4 Effects in Man, 4.2 Repeated exposure in "Lead and its inorganic compounds apart from arsenate and lead chromate," and in the section of 6.2 Threshold value, as follows: the most sensitive parameter of the toxic effects of lead in both men and women is the reduction in performance in neurobehavioral test systems. Other toxic effects of lead?especially effects on the peripheral nervous system and the kidneys, and the inhibition of haem synthesis?reach relevant levels only at much higher concentrations. Therefore, a threshold concentration for occupational exposure to lead must be derived from the NOAEL for effects on the central nervous system. In general, reproducible effects on performance are first seen at average blood lead levels of 400 microg/L (DFGOT 17 (2002)). Therefore, the blood system, kidneys, and nervous system were considered to be target organs. Based on the above, the substance was classified into Category 1 (blood system, kidneys, nervous system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information