Chemical Name:2-methyl-p-phenylenediamine sulphate
CAS:6369-59-1
ID: | 20A2137 |
Classifier: | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
Year Classified: | FY2008 |
Reference Manual: | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid (room temperature) (HSDB (2002)) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (room temperature) (HSDB (2002)) |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid (room temperature) (HSDB (2002)) |
6 | Flammable liquids | Not applicable | - | - | - | - | Solid (room temperature) (HSDB (2002)) |
7 | Flammable solid | Classification not possible | - | - | - | - | There is no data available from classification tests for flammable solids. |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (room temperature) (HSDB (2002)) |
10 | Pyrophoric solids | Classification not possible | - | - | - | - | There is no information available on its autoignition point or its properties in contact with air. |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | There is no data available on its melting point or its self-heating test. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (room temperature) (HSDB (2002)) |
14 | Oxidizing solids | Classification not possible | - | - | - | - | The substance contains oxygen (but not fluorine or chlorine), which is chemically bonded to nitrogen and sulfur. However, there is no experimental data available on its oxidizing property. |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 | Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on its rat LD50 = 98 mg/kg bw (IARC vol. 16 (1978)), the substance was classified into Category 3. | |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | - | No data available. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Solid (room temperature) (HSDB (2002)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available. |
2 | Skin corrosion/irritation | Not classified | - | - | - | - | Based on a result of a test using rabbits that the substance was mildly irritant (HSDB (2002)), it was classified into "Not classified". |
3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
Since it is reported that in a test using rabbits, the substance caused mild conjunctival reaction (HSDB (2002)), it was classified into Category 2B. |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
4 | Skin sensitization | Classification not possible | - | - | - | - | It is rated R43 (equivalent to Category 1) (EU-Annex I (accessed in August 2008)). However, due to a lack of data, classification is not possible. |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | There is no in vivo test data available, and in vitro mutagenicity tests (Ames test, chromasomal aberration test, sister chromatid exchange test) showed positive results, but they were not so strong (NTP Database (accessed in August 2008)). Therefore, the substance was classified into "Classification not possible". |
6 | Carcinogenicity | Classification not possible | - | - | - | - | Carcinogenicity tests for two years indicated, in male rats, a significant incidence of interstitial-cell tumors of the testes, and in female mice, more incidences of alveolar/bronchiolar adenomas and alveolar/bronchiolar carcinomas than those of the historical control. However, in both tests, it was concluded that there was no convincing evidence of the carcinogenicity of the substance (NTP (TR126, 1978)). Therefore, the substance was classified into "Classification not possible". |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | Teratogenicity was not noted in a rat percutaneous administration test during pregnancy (IARC vol. 16 (1978)) or in a mouse subcutaneous injection test (Teratogenic (12th, 2008)). However, neither test provided any information on parental fertility. Therefore, the substance was classified into "Classification not possible". |
8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | It is documented that in a percutaneous administration test using rats (doses, 4 - 32 mg/kg bw), no significant increase in methemoglobin levels (IARC vol. 16 (1978)). However, the test did not provide any detailed data on the test and other test information. Therefore, the substance was classified into "Classification not possible". |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | A carcinogenicity test using rats and mice (NTP (TR126, 1978)) showed only pathological findings on tumors sufficiently. A percutaneous administration test using rats for two years did not show any signs of toxic effects. However, hair dyes containing different ingredients were used as test substances: 4% 2,5-diaminotoluene sulfate or 3% 2,5-diaminotoluene and 0.75% 2,4-diaminoanisole sulfates (IARC vol. 16 (1978)). Due to the inconsistency in test substance used, the substance was classified into the "Classification not possible" category. |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible | - | - | - | - | No data available. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible | - | - | - | - | No data available. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |