GHS Classification Result

Chemical Name:citral
CAS:5392-40-5

Result:
ID: 20A2136
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Based on its flash point of 91degC (Chapman (ver. 16.1, 2008), NFPA (13th, 2006)), the substance was classified into Category 4.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 225degC (SIDS (accessed in August 2008)). Based on the classification guidance, if the autoignition point is 70degC or higher, the substance is classified into "Not classified".
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on its rat LD50 = 4960 and 6800 mg/kg bw (SIDS (accessed in August 2008)), the substance was classified into "Not classified".
1 Acute toxicity (Dermal) Not classified - - - - Based on its LD50 >= 2000 and 2250 mg/kg bw for rats and rabbits (SIDS (accessed in August 2008)), the substance was classified into "Not classified" in JIS classification (Category 5 in UN classification).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
In a 24-hour exposure test, the substance was moderately to markedly irritating to skin in rabbits, and caused moderate erythema and edema (SIDS (accessed in August 2008)). The substance is rated R38 (equivalent to Category 2 or 3) in the EU classification. Although it is reported that in humans, 1 to 8% solutions (unknown solvent) produced no irritation after 48-hour application, when 1, 4, 8% in petrolatum was applied for 24 hours, 8% in petrolatum was slightly irritating (SIDS (accessed in August 2008)). Therefore, the substance was classified into Category 2.
3 Serious eye damage/eye irritation Not classified - - - - Since in rabbits the substance was not irritating (SIDS (accessed in August 2008)), the substance was classified into "Not classified".
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Human epidermiological data and an animal test using guinea pigs indicated positive results (SIDS (accessed in August 2008)). The substance is rated R43 (equivalent to Category 1) in the EU classification (EU-Annex I (accessed in August 2008)). Therefore, the substance was classified into Category 1.
5 Germ cell mutagenicity Not classified - - - - Since two micronucleus tests (in vivo mutagenicity test using somatic cells) (mouse bone marrow and peripheral erythrocytes) showed negative results (SIDS (accessed in August 2008)), the substance was classified into "Not classified". As for in vitro tests, an Ames test and a chromosomal aberration test using Chinese hamsters showed negative results (SIDS (accessed in August 2008)), and a sister chromatid exchange test using CHO cells and a DNA damage test using mouse embryonic-stem cells indicated positive results (JECFA (Series 52 Annex 4, 6, (2004))).
6 Carcinogenicity Classification not possible - - - - In tests using rats, in both males and females, carcinogenicity has not been observed. Although in a test using mice, increased malignant lymphoma was found in females, malignant lymphoma is often difficult to distinguish from lymphoid hyperplasia, and the result was concluded to be equivocal evidence (NTP TR-505, 2003). Although the substance should be classified into "Not classified" based on the results of tests using rats, the substance was classified into "Classification not possible" based on the result of the test using mice.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since in an oral administration test using rats during pregnancy, at doses causing decreased body weight gain in parental animals, there was a dose-dependent decrease in the ratio of pregnant rats, which suggested impaired implantation or postimplantation losses (JEFCA, series 52, Annex 4, (2004)), the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In an oral administration test for 14 days using rats, at the dose of 1140 mg/kg/day (90-day conversion, 175.4 mg/kg/day), changes such as squamous metaplasia of the respiratory epithelium of the nose were revealed (SIDS (accessed in August 2008)). However, since the dose was out of the range of guidance values, the substance was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Based on its 96h-LC50 = 4.1 mg/L for fish (medaka) (SIDS, 2001), the substance was classified into Category 2.
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Although its preexisting classification for acute toxicity is Category 2, it is rapidly biodegradable (readily biodegradable; BOD degradability, 92% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1991)) and it is estimated to have low bioaccumulation potency (log Kow = 3.45 (SRC, 2005)), and therefore, the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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