Chemical Name：di-allate (ISO); S-(2,3-dichloroallyl)-N,N-diisopropylthiocarbamate
CAS：2303-16-4

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Its rat LD50 values of 393 - 1000 mg/kg (IARC vol. 30 (1983)) are within the guidance values of Category 4.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on its rabbit LD50 = 2000 - 2500 mg/kg (EHC 76 (1988), IARC vol. 30 (1983)), the substance was classified into "Not classified" in JIS classification (equivalent to Category 5 in UN classification).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	Since it was documented that in a test using rabbits, the substance is a moderate irritant to the skin (EHC 76 (1988): The pesticide manual: world compendium, 7th ed., Croydon, British Crop Protection Council), and also in human exposure, its irritation was suggested (HSFS (2004), HSDB (2003)), the substance was classified into Category 2.
3	Serious eye damage/eye irritation	Category 2		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	Since it was documented that in a test using rabbits, the substance is a moderate irritant to the skin (EHC 76 (1988): The pesticide manual: world compendium, 7th ed., Croydon, British Crop Protection Council), and also in human exposure, its irritation was suggested (HSFS (2004)), the substance was classified into Category 2.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Classification is not possible, due to a lack of in vivo test data. As relevant information, some in vitro mutagenicity tests (Ames test (EHC 76 (1988)), a mutagenicity test using mammalian cells (IARC (vol.30, 1983)), and a chromosomal aberration test using mammalian cells (IARC vol.30) indicated positive results.
6	Carcinogenicity	Not classified	-	-	-	-	Since the substance is rated Group 3 in IARC (IARC Suppl. 7 (1987)), it was classified into "Not classified".
7	Reproductive toxicity	Classification not possible	-	-	-	-	It is documented that in a test using rabbits, the substance did not show any teratogenicity (Birth Defects 3rd (2000)). However, since there is no other data available, classification is not possible.
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	It is reported that in a rat oral administration test, its effects on the nervous system occurred at high dose levels tested (IARC (vo.12, 1976), EHC 76 (1988)). However, due to a lack of data, the substance was classified into "Classification not possible".
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	It is documented that in a 90-day oral administration (diet) test using rats, at the dose of 8 mg/kg/day, irritability, hyperactivity, and mild cardiac changes occurred (EHC 76 (1988)). However, since there is no other data available, classification is not possible.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 2	-	-	H401: Toxic to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	Since its 96h-LC50 = 5.9 mg/L for fish (bluegills) (EHC 78 (1988)), the substance was classified into Category 2.
11	Hazardous to the aquatic environment （Long-term）	Category 2		-	H411: Toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Its preexisting classification for acute toxicity is Category 2, it is not rapidly biodegradable (SRC: BioWin V4.10) and it is estimated to have high bioconcentration potency (log Pow = 4.49, PHYSPROP Database (2008)), and therefore, the substance was classified into Category 2.