GHS Classification Result

Chemical Name：2-methylcyclohexanone
CAS：583-60-8

Result：
ID: 20A2121
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Its flash point is 48degC (c. c.; Ullmanns (E) (6th, 2003)), which is above 23degC and below 60degC.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on its LD50 = 2.14 mL/kg = 1977 mg/kg for rats (PATTY (5th, 2001)), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on its LD50 = 1.77 mL/kg = 1637 mg/kg for rabbits (PATTY (5th, 2001)), the substance was classified into Category 4.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Since inhalation of 2800 ppm of the substance for 4 hours killed three of six rats (ACGIH (2001)), and it is rated R20 in the EU classification, the substance was classified into Category 4. As relevant information, since the saturated vapour pressure concentration at 25degC is 3950 ppm, the substance is considered to be a vapour with almost no included mists at the test concentration (2800 ppm).
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - The substance was moderately irritating when held in contact with the skin of guinea pigs for 24 hours (PATTY (5th, 2001)). However, since it was mildly irritating to rabbit skin, producing a grade 3 response (range 1 to 10) when left in contact with the skin for 24 hours (PATTY (5th, 2001))., the substance was classified into "Not classified" in JIS classification (equivalent to Category 3 in UN GHS). As relevant information, it is said that repeated open application of the substance in humans did not cause irritation (GESTIS (accessed in August 2008)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the result of grade 5 (scale of 1 to 10), as it causes severe corneal burn when applied to the eyes of rabbits (PATTY (5th, 2001)), the substance was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation, Narcotic effects） Warning H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		As the results of a mouse inhalation exposure test of 2-methylcyclohexanone, irritating to the eyes and respiratory tract has been reported (PATTY (5th, 2001)), and as characteristics of an isomeric mixture of methylcyclohexanones, at low concentrations, it was described to be irritating to the eyes, the nasal cavity, and the throat (PATTY (5th, 2001)). In addition, anesthesia and hypothermia were observed in rabbits that survived dermal administration of 2-methylcyclohexanone (PATTY (5th, 2001)), and rabbits or cats became somnolent within one hour after exposure to 2-methylcyclohexanone via inhalation (ACGIH (2001)). Also as characteristics of high concentration exposure of an isomeric mixture of methylcyclohexanones, inhibition of the central nervous system and anesthesia were indicated (PATTY (5th, 2001)). Based on the above results, the substance was classified into Category 3 (respiratory tract irritation, narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - A test in which rabbits were exposed by inhalation of an isomeric mixture of methylcyclohexanones solely provided data on repeated exposure. Exposure of methylcyclohexanones at 182 and 514 ppms for 10 weeks (90-day conversion, 0.64, 1.81 mg/L) or 1139 and 1822 ppms for 3 weeks (90-day conversion, 1.21, 2.04 mg/L) caused a few minor effects, including slight conjunctival congestion, but no major toxicities (PATTY (5th, 2001)). However, since the test substance was not 2-methylcyclohexanone but an isomeric mixture of methylcyclohexanones, the tested animal species was rabbit only and the test was performed many years ago (1943), and details of the testing design, including the number of used animals, inspected organs (other than the liver and the kidneys) are not indicated, it is doubtful that the substance should be classified into "Not classified", so it was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Based on its 24h-EC50 = 377 mg/L for crustaceans (Daphinia magna) (ECOTOX, 2008), the substance was classified into "Not classified".
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since the substance is water soluble (water solubility, 5142 mg/L (SRC, 2005)) and its preexisting classification for acute toxicity is "Not classified", it was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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