GHS Classification Result

Chemical Name:malachite green hydrochloride
CAS:569-64-2

Result:
ID: 20A2119
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not applicable - - - - The substance contains chlorine (but not oxygen or fluorine), which is ionically bonded and forms a chloride. Accordingly, it lacks oxidizability.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on its mouse LD50 = 80 mg/kg (HSDB (2005)), the substance was classified into Category 3.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
"Eye-damage in humans" is reported (NTP TOX. 71, 2004), and in rabbits, "injury ranging in severity from conjunctival edema, hyperemia, and purulent discharge to total opacification and even necrosis and sloughing of corneal stroma" is described (HSDB (2005)). Since the substance is rated R41 (equivalent to Category 1) in the EU classification (EU-Annex 1 (accessed in August 2008)), it was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - Based on negative results of a micronucleus test using rats and mice (NTP DB (accessed in September 2008)) (NTP TR572, 2005), the substance was classified into "Not classified".
6 Carcinogenicity Classification not possible - - - - In a two-year feed study using female rats (0 - 600 ppm, two years), the occurrence of tumors in thyroid gland cells, hepatocytes, and mammary gland cells was observed. However, since it was considered to be "equivocal evidence" (NTP TR572, 2005), the substance was classified into "Classification not possible".
7 Reproductive toxicity Classification not possible - - - - In an oral test by gavage using rats (50 or 500 mg/kg during critical period of pregnancy), no effect on the rate of malformations was observed (HSDB (2004)). However, since the test does not provide any data on parental fertility, and there is no other information available, and due to the lack of data, the substance was classified into "Classification not possible".
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Category 2 (blood) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In a rat-diet study (0 - 1200 ppm, 28 days) (NTP TOX. 71, 2004), significant reduction of erythrocyte count, hemoglobin level, and hematocrit level was observed in the female 1200 ppm group (90-day conversion, 50 mg/kg bw). In a mouse diet study (0 - 1200 ppm, 28 days) (NTP TOX. 71, 2004), significant reduction of erythrocyte count, hemoglobin level, and hematocrit level, and significant increase of reticulocyte count were observed in the male and female 300 ppm groups (90-day conversion, 21 mg/kg bw). The blood changes and these findings observed in rats and mice were described to be "indicative of anemia," and therefore, the substance was classified into Category 2 (blood).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its 96h-LC50 = 0.0305 mg/L for fish (bluegills) (AQUIRE, 2008), the substance was classified into Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its preexisting classification for acute toxicity is Category 1, and it is not rapidly biodegradable (non-biodegradable; BOD degradability, 0.3% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1983)), the substance was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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