GHS Classification Result

Chemical Name：butyraldehyde
CAS：123-72-8

Result：
ID: 20A2110
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since its flash point is -6.67degC (closed cup) (Merck 14th (2006) No. 1591), and its initial boiling point is 74.8degC (Merck 14th (2006) No. 1591; Ullmanns (E) 6th, 2003, vol. 5), the substance was classified into Category 2. As relevant information, also in TDG classification, since the substance fits in Class 3, Packing group II, it is classified into Category 2.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its autoignition point is 190degC - 230degC (Chapman Ver. 16, 1 (2008); NFPA 13th, 2006; Hommel (1996)), which is above 70degC, and the substance fits in Class 3 in TDG classification (UN No. 1129), it was classified into "Not classified".
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on its LD50 values of 2490, 2500, 4160, 5890, and 5900 mg/kg bw for rats (IUCLID, 2000), the substance was classified into "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - Based on its LD50 value of 5730 microL/kg (specific gravity conversion, 4584 mg/kg) for rabbits (Patty 5th vol. 5, 2001), the substance was classified into "Not classified" in JIS classification. In addition, it fits in Category 5 in UN classification.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - Given that its vapour pressure is 111 mmHg (conversion value: 14796 Pa at 25degC) (HSDB, 2003), its saturated vapour pressure concentration is calculated to be approx. 146495 ppm. In a 30-minute inhalation test using rats, its LC50 value was found to be 60000 ppm (PATTY 5th vol. 5, 2001), which was below 90% of its saturated vapour pressure concentration. Thus, the classification was conducted under the assumption that this test was carried out in a vapour with almost no included mists. Since the 4-hour LC50 is calculated to be 21213 ppm, based on the LC50 of 60000 ppm obtained in the 30-minute test, the substance falls under the"Not classified" category.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - Since it is documented that in two tests using rabbits (both tests are in compliant with OECD TG 404, GLP), the substance was either not irritating or slightly irritating (IUCLID (2000)), it was classified into the "Not classified" category using JIS classification criteria (Category 3 in UN classification).
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Since it is described that in six instances of industrial corneal injury from butyraldehyde recovery was prompt and complete (HSDB, 2003), and in a test using rabbits according to OECD TG 405 (GLP) the substance was slightly irritating (IUCLID (2000)), it was classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - Since the substance was negative in a peripheral blood micronucleus test using mice (in vivo mutagenicity test using somatic cells) (Evaluation of effect for the food safety (Food Safety Commission), 2007), it was classified into "Not classified". As relevant information, as for in vitro tests, the substance was negative in two Ames tests (PATTY 5th vol. 5, 2001; Evaluation of effect for the food safety (Food Safety Commission), 2007), negative in a cytogenetical test using CHO cells (IUCLID (2000)), negative in a sister chromatid exchange tests using human lymphocytes (IUCLID (2000)), negative in an unscheduled DNA synthesis test using human hepatocytes (IUCLID (2000)), positive in a HGPRT test (IUCLID (2000)), positive in a sister chromatid exchange test using CHO cells (IUCLID (2000)), positive in a chromosomal aberration test using CHL/IU cells (Evaluation of effect for the food safety (Food Safety Commission), 2007), and weakly positive in an unscheduled DNA synthesis test using rat hepatocytes (PATTY 5th vol. 5, 2001).
6 Carcinogenicity Classification not possible - - - - As for human effects, it is documented that exposure to butyraldehyde may be implicated in observed associations between the occurrence of respiratory epithelium cancer in workers and lung cancer associated with high-temperature cooking; however, coexposures with other more reactive aldehydes do not support the role of butyraldehyde acting alone (PATTY 5th vol. 5, 2001), and therefore, the substance was classified into "Classification not possible".
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system) Danger H370: Causes damage to organs (respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since it is reported that in humans, the substance is extremely destructive of tissues of the mucosal membranes and upper respiratory tract (PATTY 5th vol. 5, 2001), and inhalation exposures to more than 6000 ppm (17.7 mg/L, vapour) or more produce bronchial and alveolar edema in rodents (PATTY 5th vol. 5, 2001), the substance was classified into Category 1 (respiratory organ).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - It is documented that in a 90-day gavage administration test using rats (Evaluation of effect for the food safety (Food Safety Commission), 2007), the 300 mg/kg bw group showed slight squamous cell hyperplasia at the anterior stomach/glandular stomach border or in the anterior stomach, and in the 1200 mg/kg bw group, ulcerous lesions were observed in the anterior stomach/glandular stomach, and in males that received 300 mg/kg bw or more and females that received 600 mg/kg bw or more, inflammation was observed in the nasal cavity, and from these results, it is concluded that the NOAEL is 100 mg/kg bw and NOEL are 150 mg/kg bw for males and 300 mg/kg bw for females. Since these values of NOAEL are equal to or greater than the upper guidance value, the substance should be classified into "Not classified" (oral). However, since data on other routes are not sufficient, and due to the lack of data, the substance was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		As its 96h-LC50 is 13.4 mg/L for fish (fathead minnow) (AQUIRE, 2008), the substance was classified into Category 3.
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Although its preexisting classification for acute toxicity is Category 3, it is rapidly biodegradable (readily biodegradable, BOD degradability, 100% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1979)), and it is estimated to have low bioaccumulation potency (log Kow = 0.88 (SRC, 2005)), and therefore, the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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