GHS Classification Result

Chemical Name：4-CPA
CAS：122-88-3

Result：
ID: 20A2109
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains chlorine and oxygen (but not fluorine), which are chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid (melting point >= 55degC) substances are not available. As relevant information, it is described that its solution corrodes brass, zinc, and copper (HSDB (2003)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Its rat LD50 values documented were 850 mg/kg (HSDB (2006)) and 2703 mg/kg (EPA RED (accessed in March 2009)). Based on the smaller value, which indicates higher toxicity, the substance was classified into Category 4. As relevant information, it is rated R22 in the EU classification.
1 Acute toxicity （Dermal） Not classified - - - - Based on its LD50 of > 2000 mg/kg for rabbits (HSDB (2006)), the substance was classified into the "Not classified" category using the JIS classification criteria (Category 5 or the "Not classified" category in the United Nations GHS classification).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Based on its rat LC50 > 5.25 mg/L (EPA RED (accessed in March 2009)), the substance was classified into "Not classified". Since its saturated vapour concentration is 0.0032 mg/L, test animals were presumably exposed to dust.
2 Skin corrosion/irritation Not classified - - - - Since it is reported that the substance was non-irritating in a primary dermal irritation study with rabbits (HSDB (2006); EPA 738-R-97-001, March 1997), the substance was classified into "Not classified".
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Since it is reported that in rabbits, the substance was a severe eye irritant (HSDB (2006); EPA 738-R-97-001, March 1997), the substance was classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - It is described that no sensitization occurred in a dermal sensitization study with guinea pigs (HSDB (2006); EPA 738-R-97-001, March 1997), and the substance should be classified into "Not classified". However, since it is a List 2 datum, the substance was classified into "Classification not possible".
5 Germ cell mutagenicity Classification not possible - - - - Since there is no in vivo test data available, classification is not possible. As relevant information, in in vitro mutagenicity tests, the mutagenicity of the substance tested with bacteria (Salmonella typhimurium and Escherichia coli) and tested in mouse lymphoma cells was negative (HSDB (2006)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - It is described that in a rat developmental toxicity test by gavage during the organogenetic period, the high-dose group showed, as general signs in addition to decreased body weight gain in maternal animals, tremors and uncoordinated movements, decreased fetal body weights, skeletal variations at the sternebrae and cervical ribs, etc., while teratogenicity and other adverse effects are not described (HSDB (2006)). However, since this test provides no data about the effects on sexual functions and fertility of parental animals, classification is not possible.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In an acute oral toxicity study in rats, at the dose of 2703 mg/kg, clinical signs of toxicity were staggered gait, hypoactivity, and absent pain reflex (EPA RED (accessed in March 2009)). However, since there is no other available data, and due to a lack of data, the substance was classified into "Classification not possible".
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a 13-week oral toxicity study using rats, the NOEL was 2000 ppm (132 mg/kg/day (males), 153 mg/kg/day (females)) (HSDB (2006)), which was above the upper guidance value of Category 2, and the substance should be classified into "Not classified" (oral). However, since it is a List 2 datum and there is no information on other routes, the substance was classified into "Classification not possible". As relevant information, at the highest dose for males, 8000 ppm (517 mg/kg/day), slightly increased incidences of hepatic lymphohistocytic infiltration and hepatocellular necrosis were seen (HSDB (2006)). In addition, the substance was given to dogs for 13 weeks in the diet, but the direct effects were not observed, and the NOEL was reported to be 500 ppm (17.4 - 18.6 mg/kg/day) (HSDB (2006)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Since its 96h-LC50 > 180 mg/L for fish (bluegills) (Aquire, 2008), the substance was classified into "Not classified".
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since its preexisting classification for acute toxicity is "Not classified", and it is water-soluble (water solubility = 957 mg/L (PHYSPROP Database, 2008)), the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information