Chemical Name：2-methyl-4-oxo-3-(penta-2,4-dienyl)cyclopent-2-enyl[1R-[1alpha[S*(Z)](3beta)]]-3-(3-methoxy-2-methyl-3-oxoprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate; pyrethrin II
CAS：121-29-9

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Based on its LD50 = 1.2 g/kg for rats (HSDB (2005)), the substance was classified into Category 4. Pyrethrin II is an ingredient of Pyrethrum (a mixture of ingredients of Pyrethrin I, Pyrethrin II, Cinerin I, Cinerin II, and Jasmolin).
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (room temperature)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	The rat LC50 = 3.4 mg/L/4h of the Pyrethrin mixture (Pyrethrin I and Pyrethrin II) (HSDB (2005)). However, there is no data on Pyrethrin II itself, and therefore, classification is not possible. (Refer to ID 906 (NITE), Pyrethrum, CAS No. 8003-34-7.)
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	When 200 people were patch tested with a 1% water dispersion of the Pyrethrin mixture (Pyrethrin I and Pyrethrin II), no evidence of primary irritancy was found (HSDB (2005)). However, there is no data on Pyrethrin II itself, and therefore, classification is not possible. (Refer to ID 906 (NITE), Pyrethrum, CAS No. 8003-34-7.)
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	It is documented that in humans, the Pyrethrin mixture consisting of Pyrethrin I and II in pure form may cause transient conjunctival edema and hyperemia and is irritating to eyes and mucous membranes; however, no persistent ocular disturbance from pyrethrum or its derivatives appears to have been reported (HSDB (2005)). The effects are transient and reversible, and therefore, the substance was classified into Category 2B. Refer to ID 906 (NITE), Pyrethrum, CAS No. 8003-34-7.
4	Respiratory sensitization	Classification not possible	-	-	-	-	A case has been reported of a 36-year-old woman with a history of asthma who developed severe shortness of breath five minutes after she began to wash her dog with an insecticide shampoo containing 0.05% of the Pyrethrin mixture (Pyrethrin I and Pyrethrin II). She soon developed gasping respiration. In five minutes, she was in cardiopulmonary arrest, and she died (HSDB (2005)). In addition, an asthma-like reaction (hypersensitive pneumonitis) occurred in sensitized patients with exposure to Pyrethrins has been reported (HSDB (2005)). However, its respiratory sensitization has not been concluded to be positive in all cases, and therefore classification is not possible. Refer to ID 906 (NITE), Pyrethrum, CAS No. 8003-34-7.
4	Skin sensitization	Classification not possible	-	-	-	-	A case in which a patient with a history of allergic dermatitis from pyrethrum showed positive patch-test responses not only to pyrethrum flower heads and extracts but also to Pyrethrin II has been reported (HSDB (2005)). On the other hand, it has been reported that when 200 people were patch tested with a 1% water dispersion of the Pyrethrin mixture (Pyrethrin I and Pyrethrin II), no evidence of sensitization was found (HSDB (2005)). In addition, the sensitizing properties of the Pyrethrin mixture (Pyrethrin I and Pyrethrin II) were suggested to be associated with impurities of the test substances (HSDB (2005)). As described above, no certain conclusions on skin sensitization have been established, and therefore, classification is not possible. (Refer to ID 906 (NITE), Pyrethrum, CAS No. 8003-34-7.)
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	No data available. Refer to ID 906 (NITE), Pyrethrum, CAS No. 8003-34-7.
6	Carcinogenicity	Classification not possible	-	-	-	-	Pyrethrum is rated as A4 in the ACGIH classification (HSDB (2005)), which is equivalent to the "Not classified" category in the GHS classificaiton. However, there is no information available to classify Pyrethrin II into "Not classified", and due to the lack of data, classification is not possible. (Refer to ID 906 (NITE), Pyrethrum, CAS No. 8003-34-7.)
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data available. (Refer to ID 906 (NITE), Pyrethrum, CAS No. 8003-34-7.)
8	Specific target organ toxicity - Single exposure	Category 3 （Respiratory tract irritation）		Warning	H335: May cause respiratory irritation (respiratory tract irritation)	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ...	Human clinical manifestations of inhalation exposure to pyrethrum and synthetic pyrethroids including the following have been indicated: in the upper respiratory tract, rhinitis, oral mucosal edema, and laryngeal mucosal edema; in the lower respiratory tract, cough, shortness of breath, and chest pain (HSDB (2005)). And it is described that Pyrethrin II in pure form is irritating to skin, eyes, respiratory tracts, and mucous membranes (HSDB (2005)). Therefore, the substance was classified into Category 3 (respiratory tract irritation). (Refer to ID 906 (NITE), Pyrethrum, CAS No. 8003-34-7.)
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	When the Pyrethrin mixture (Pyrethrin I and Pyrethrin II) were fed for two years (the animal species are not shown), liver lesions were reported (HSDB (2005)). However, since Pyrethrin II itself was not used and the obtained data were insufficient, classification is not possible. (Refer to ID 906 (NITE), Pyrethrum, CAS No. 8003-34-7.)
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Based on its 48h-LC50 = 0.017 mg/L for crustaceans (Daphinia magna) (ECOTOX, 2008), the substance was classified into Category 1.
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since its preexisting classification for acute toxicity is Category 1, and it is not rapidly degradable (SRC, BioWin V4.10), the substance was classified into Category 1.