GHS Classification Result

Chemical Name:1,2,3,4-tetrahydronaphthalene
CAS:119-64-2

Result:
ID: 20A2107
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Its flash point is 82degC (Merck (14th, 2006), HSDB (2003)), which is above 60degC and below 93degC.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 385degC (HSDB (2003), ICSC (2004), NFPA (13th, 2006)), which is above 70degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance does not contain oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Its rat LD50 is 2860 mg/kg bw (SIDS (accessed in August 2008)), which is equivalent to the guidance value of Not classified in JIS classification criteria (equivalent to Category 5 in UN classification).
1 Acute toxicity (Dermal) Not classified - - - - Since its rabbit LD50 is ca. 16800 mg/kg bw (SIDS (accessed in August 2008)) or 17300 mg/kg bw (PATTY (5th, 2001)) and its rat LDLo is above 7300 mg/kg bw (PATTY (5th, 2001)), the substance was classified into "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Its guinea pig LC50 measured with vapour being 275 ppm (8h-exposure) (4h-conversion, 389 ppm, 2.10 mg/L) (PATTY (2000)) is equivalent to the guidance value of Category 2. As relevant information, since the saturated vapour concentration is 488 ppm, the test was considered to be performed with vapour with almost no included mists (evaluation with gas evaluated values).
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification not possible due to lack of data. As relevant information, it is reported that its rat LCLo measured with mist is above 1.3 mg/L (4h-conversion, 2.6 mg/L) (quivalent to Category 4 or "Not classified") (PATTY (5th, 2001)).
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
In a four-hour skin irritation study according to OECD TG 404 using rabbits, the substance caused moderate irritation with Draize scores of 3.11 for erythema and 1.56 for edema, and the effects were not completely reversible within 14 days (SIDS (accessed in August 2008)). In addition, since its EU Risk Phrase is R36/38, which indicates that its hazard potential is equivalent to Category 2, the substance was classified into Category 2.
3 Serious eye damage/eye irritation Not classified - - - - In a Draize study with rabbits according to OECD TG 405, the substance caused no significant irritation, with a Draize mean score of 5.17/110, and the effects were completely reversible within six days. Also, in another study using rabbits, 0.5 mL of the substance was applied, and the substance caused slight irritation but no damage, with a Draize score of 1/10 (SIDS (accessed in August 2008)). Therefore, the substance was classified into "Not classified". As relevant information, SIDS concluded that animal tests showed no irritation, but high exposure from the gas phase may cause irritation and profuse lacrimation in humans. PATTY and HSDB also documented that the substance is irritating to humans, but they do not report any symptoms caused by the substance (based on expert judgment).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - It is documented that in a guinea pig maximization test according to OECD TG 406, the substance was not sensitizing (SIDS (accessed in August 2008)). Therefore, the substance was classified into "Not classified".
5 Germ cell mutagenicity Not classified - - - - Since the substance was negative in a micronucleus test by gavage using mice (SIDS (accessed in August 2008), IUCLID (2000)), and negative in a micronucleus test by inhalation using mice (six-hours/day, 13-weeks) (SIDS (accessed in August 2008)) (both were in vivo mutagenicity tests using somatic cells), the substance was classified into "Not classified". As additional background information, regarding in-vitro mutagenicity tests, Ames tests gave negative results while mouse lymphoma tests yielded both positive and negative results, making the mutagenicity evaluation of the substance inconclusive (SIDS (accessed in August 2008)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - The substance did not show any effects on fetuses in a developmental toxicity test using rats performed in accordance with OECD TG 414 (SIDS (accessed in August 2008)). In a mouse inhalation test for 13-weeks (six-hours/day, five-days/week), uretus atrophy and atrophy of the ovary were found (SIDS (accessed in August 2008)). However, since there is no available test data on sexual functions and fertility, and due to the lack of data, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects) Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
In a rat oral administration test, at the doses of 2000 mg/kg or more, the rats exhibited symptoms of sluggishness, prostration, and narcosis (SIDS (accessed in August 2008)), and in humans, signs such as headache and stupor have been reported (SIDS (accessed in August 2008)). Therefore, the substance was classified into Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Category 2 (blood) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In a 28-day toxicity study in rats with gavage, at the dose of 150 mg/kg/day, hemolytic anemia was seen, which was present at two weeks after the end of the administration period, and as the secondary reactions, increased reticulocyte counts and enhanced extramedullary hematopoesis in the spleen have been reported (SIDS (accessed in August 2008)). While, in a 13-week inhalation test in rats or mice, mainly at the doses of 0.333 mg/L and 0.666 mg/L, changes of blood indexes, including regenerative anemia or reduced erythrocyte count, were reported (SIDS (accessed in August 2008)). Based on the above results, since the developmental doses of hemolytic anemia and related signs, that is, 150 mg/kg/day In the 28-day toxicity study with gavage (90-day conversion, 46.7 mg/kg/day) and 0.333 mg/L and 0.666 mg/L in the 13-week inhalation test are within the guidance values of Category 2, the substance was classified into Category 2 (blood). As relevant information, the toxicological meanings of other changes seen mainly in high-dose groups are unknown.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since its 96h-LC50 = 3.2 mg/L (SIDS, 2008) for fish (zebra fish), the substance was classified into Category 2.
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Although its preexisting classification for acute toxicity is Category 2, it is rapidly biodegradable (BOD degradability, 81% (SIDS, 2006)) and it is estimated to have low bioaccumulation potency (log Kow = 3.78 (SIDS, 2006)), and therefore, the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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