GHS Classification Result

Chemical Name:tetrachlorophthalic anhydride
CAS:117-08-8

Result:
ID: 20A2105
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available. As relevant information, the substance is described to be used as a flame retardant in plastics (NTP TOX-28 (1993)).
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available. As relevant information, the substance is described to be used as a flame retardant in plastics (NTP TOX-28 (1993)).
11 Self-heating substances and mixtures Classification not possible - - - - No data available. As relevant information, the substance is described to be used as a flame retardant in plastics (NTP TOX-28 (1993)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains chlorine and oxygen (but not fluorine), which are chemically bonded only to hydrogen or carbon.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Its melting point is 55degC or higher. Test methods applicable to solid (melting point >= 55degC) substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Since its rat LD50 > 15800 mg/kg (NTP TOX-28 (1993)), the substance was classified into "Not classified".
1 Acute toxicity (Dermal) Not classified - - - - Since its rat LD50 > 5000 mg/kg (NTP TOX-28 (1993)), the substance was classified into "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
"Slight irritation" was reported in eye irritation tests using rabbits with 10% suspension in corn oil and with powder (NTP TOX-28 (1993)). Therefore, it was classified into Category 2B.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ...
There is the following description in the List 1 (NTP TOX-28 (1993)). As human toxicities, several cases of the occupational disease (asthma) attributed to exposure to the substance have been reported in literature. In one case, five workers involved in the production of epoxy resins developed respiratory symptoms and physiologic abnormalities following the introduction of the substance into the product formation. Inhalation challenge tests with the substance in three of the five workers reproduced their symptoms and resulted in both immediate and delayed responses. Immunologic studies did not demonstrate specific antibodies; however, clinical signs suggested a hypersensitivity reaction rather than an irritant effect. The presence of IgE antibody specific to the substance was later reported in seven female workers exposed to the chemical via an epoxy resin; the antibody was identified following skin-prick and radioallergosorbent tests (radioactive allergen absorption test). Based on the above descriptions, the substance was classified into Category 1.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - In a chromosomal aberration test using mouse bone marrow (in vivo mutagenicity tests using somatic cells), the substance was negative (NTP TOX-28 (1993)), and therefore, it was classified into "Not classified". As relevant information, it is described that in sister chromatid exchange (SCE) tests (in vivo genotoxicity tests using somatic cells), the substance showed negative results, and the observed SCE frequencies increased dose-dependently, but they were small, and in one of the dose groups, the degree of increase in SCE frequencies was less than that of the control group (NTP TOX-28 (1993)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - It is described that in a developmental toxicity test in which rats were gavaged during the pregnancy period, including the organogenetic period, except for a slight increase in the incidence of skeletal malformation of fetuses in the 2000 mg/kg administration group, embryotoxicity and fetal toxicity, teratogenicity, and toxicities to parental animals were not detected (NTP TOX-28 (1993)). Also, it is documented that in an oral gavage test for 13-weeks using rats and mice, no abnormality of testis morphology or vaginal cells were observed (NTP TOX-28 (1993)). However, no data on reproductive toxicity is available, and due to the lack of data, classification is not possible.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Category 1 (lung) Danger H372: Cause damage to organs through prolonged or repeated exposure (lung) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
It is described that in an inhalation exposure test with dust or fumes of the substance for 13 weeks using rats, at the exposure range of 0.0005 - 0.05 mg/L/6h/day, hepatocellular hypertrophy and increased lung weights associated with multifocal accumulations of aveolar macrophages and alveolar hemorrhage were observed dose-dependently. Also, it is documented that in a test for four weeks, fumes at 0.04 mg/L/6h/day (90 day conversion, approximately 0.01 mg/L/6h/day) was recognized to adversely affected the lungs (NTP TOX-28 (1993)), and the dose is within the guidance values of Category 1, the substance was classified into Category 1 (lung). As relevant information, in an oral administration test by gavage for 13 weeks using rats, affects on the kidneys, for example, at the dose of 187 mg/kg/day, dilation of the renal tubular, at higher doses, necrosis were observed, and the NOAEL was 94 mg/kg/day. While it is described that in a test using mice, even at the dose of 1500 mg/kg/day, no histopathological change was observed (NTP TOX-28 (1993)). Since these doses are above the guidance values of Category 2, as for oral administration, the substance is classified into "Not classified".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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