GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：hexafluoropropene; hexafluoropropylene
CAS：116-15-4
Result：
| ID: | 20A2104 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2008 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （Sep, 2008） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Flammable gases （including chemically unstable gases） | Not classified | - | - | - | - | Nonflammable (IMDG (2006) vol. 2) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not classified | - | - | - | - | The substance belongs to "Group 1" in ISO 5145: 2004 (non-flammable, non-toxic gases). |
| 5 | Gases under pressure | Low pressure liquefied gas |
|
Warning | H280: Contains gas under pressure; may explode if heated | P410+P403: Protect from sunlight. Store in a well-ventilated place. | Since its boiling point is -156.2degC at standard pressure (Ullmanns (E) (6th, 2003) vol. 14), the substance completely gasifies at 20degC, and its critical temperature is 86.2degC (Ullmanns (E) (6th, 2003) vol. 14), which is above 65degC. |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 7 | Flammable solid | Not applicable | - | - | - | - | Gas (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 11 | Self-heating substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Gas (GHS definition) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Gas (GHS definition) |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to gaseous substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Category 4 |
|
Warning | H332: Harmful if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Its four 4h-LC50 values for rats (> 1200, 1830, 2800, and 3060 ppm) were found (ECETOC JACC 48 (2005)), one of which is equal to the guide value of Category 3 to Not classified, one of Category 3, and two of Category 4, and therefore, the substance was classified into Category 4. |
| 1 | Acute toxicity （Inhalation: Vapours） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on the negative results of both a dominant lethal test using rats with inhalation exposure (an in vivo heritable mutagenicity test using germ cells) and a micronucleus test using bone-marrow cells in inhalation-exposed mice (in vivo mutagenicity tests using somatic cells) (ECETOC JACC 48 (2005)), the substance was classified into "Not classified". As relevant information, a rat unscheduled DNA synthesis test using inhalation exposed liver cells (in vivo genotoxicity tests using somatic cells) showed negative results (ECETOC JACC 48 (2005)), and an Ames test (an in vitro test) indicated negative results, while a chromosomal aberration test using CHO cells provided positive results (ECETOC JACC 48 (2005)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (kidney) |
|
Danger | H370: Causes damage to organs (kidney) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
In rats, after inhalation for four hours at 320 ppm or higher, necrosis and regeneration of renal tubules, and also in mice, guinea pigs, and rabbits, at 1000 ppm or higher, nephrosis was observed (ECETOC JACC 48 (2005), ACGIH (2007)). Since these effects were recognized at a dose being equivalent to the guidance value of Category 1, the substance was classified into Category 1 (kidney). As relevant information, at the lethal dose or high concentrations being near the lethal dose, pulmonary congestion and oedema, and central nervous system symptoms, such as depression, loss of coordination, and clonic spasms, were reported (ECETOC JACC 48 (2005)). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (kidney) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (kidney) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
In mice that received inhalation for 90 days (six hours/day) at 50 ppm or higher, histological kidney lesions (regeneration of the inner cortical tubules, cytomegaly of the tubular epithelium, and tubular epithelial necrosis) were observed (ECETOC JACC (2005)). And an inhalation test using rats for 14 days (six hours/day) at 200 ppm (90 day conversion, 31.1 ppm) showed nephrosis characterized by degeneration of the inner cortical tubules (ECETOC JACC (2005)). Since effects on the kidneys were recognized both in mice and rats at a concentration equivalent to the guidance value of Category 1, the substance was classified into Category 1 (kidney). |
| 10 | Aspiration hazard | Not applicable | - | - | - | - | Gas (GHS definition) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |