GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：dimethyl ether
CAS：115-10-6
Result：
| ID: | 20A2102 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2008 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （Sep, 2008） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Flammable gases （including chemically unstable gases） | Category 1 |
|
Danger | H220: Extremely flammable gas |
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking. P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely. P381: Eliminate all ignition sources if safe to do so. P403: Store in a well-ventilated place. |
Its explosion limit is 3.4?18 vol%, and its explosive range is 12% or more. (UNRTDG2.1 and ERG Guide No.115) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not classified | - | - | - | - | Since the substance is a flammable gas, it is not oxidative. |
| 5 | Gases under pressure | Low pressure liquefied gas |
|
Warning | H280: Contains gas under pressure; may explode if heated | P410+P403: Protect from sunlight. Store in a well-ventilated place. | Since its boiling point is -24.8degC (Merck (14th, 2006), Ullmanns (6th, 2003), Howard (1997), HODOC (3rd, 1997), Lide (88th, 2008), HSDB (2008), ICSC (2002), ICSC (J) (2002)), and its critical temperature is 126.95degC (Matheson (7th, 2001)), the substance is a low-pressure liquefied gas. |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 7 | Flammable solid | Not applicable | - | - | - | - | Gas (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 11 | Self-heating substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Gas (GHS definition) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Gas (GHS definition) |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to gaseous substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not classified | - | - | - | - | In an inhalation test (4h-exposure) using rats, its LC50 is 164000 ppm (DFGOT (vol. 1, 1991), PATTY (5th, 2001)), and therefore, the substance was classified into "Not classified". |
| 1 | Acute toxicity （Inhalation: Vapours） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | There is no available in vivo data, and available in vitro data are only the negative results in a mutagenicity test (DFGOT (vol. 1, 1991), IUCLID (2000)). Therefore, the substance was classified into "Classification not possible". |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | In an inhalation exposure test using rats for 104 weeks (6 hours/day, 5 days/week), the incidence of benign and malignant mammary tumors (52.8%) in the dose group significantly increased above that in the control group (36%) but was not considered to be substance-related since mammary tumors had been present with a frequency of 53% in 436 historical rats in control groups in the laboratory (DFGOT (vol. 1, 1991); PATTY (6th, 2001); IUCLID (2000)). Since this was the only test, and due to the lack of data, the substance was classified into "Classification not possible". |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | In a rat test, inhalation of 6 hours per day for 13 days before mating caused no effect on the mating behavior or on the number of pregnancies observed. From day 6 to day 16 of gestation, the pregnant rats were exposed for 6 hours per day to the same substance, and no significant changes in fetuses were found (DFGOT (vol. 1, 1991)). However, since there is no male reproductive toxicity information available, the substance was classified into "Classification not possible". The substance is also rated as D (Classification not possible to measure pregrancy risk) by the DFG (MAK/BAT, 2007). |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Narcotic effects） |
|
Warning | H336: May cause drowsiness or dizziness (narcotic effects) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
Since it is described that in a rabbit inhalation test (45 minutes) and in a dog inhalation test (five minutes) performed at doses above guidance values, anaesthesia, reduced blood pressure, and increased heart rate were seen (DFGOT (vol. 1, 1991)), and in humans, effects on the nervous system, such as unconsciousness, visual defects, and analgesia, were observed, the substance was classified into Category 3 (narcotic effects). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | In a 14-day inhalation test using rats (6 hours/day, 5 days/week), at the dose of 10000 ppm, the only significant effect was reduced body weight, and the NOAEL was determined to be < 10000 ppm. In addition, in a 13-week inhalation test using rats (6 hours/day, 5 days/week), at the dose of 20000 ppm, increased SGOT values, reduction in liver weight, and increased SGPT activity were observed, while at the dose of 2000 ppm, they were not observed. In a 13-week inhalation test using hamsters (6 hours/day, 5 days/week), at the dose of 20000 ppm, a significant reduction in the number of leukocytes was found (DFGOT (vol. 1, 1991)), but at the dose of 10000 ppm, the reduction was not significant, and the NOAEL was determined to be 5000 ppm. Since each of these doses is above the guidance value of Category 2 the substance should be equivalent to "Not classified (inhalation)." However, since there is no data on other route available, and due to the lack of data, the substance was classified into "Classification not possible". |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Not classified | - | - | - | - | Based on its 96h-LC50 > 4000 mg/L for fish (guppies) and 48h-EC50 > 4000 mg/L for crustaceans (Daphnia magna) (both from IUCLID, 2000), the substance was classified into "Not classified". |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Since it is water soluble (water solubility, 4.6E+004 mg/L (PHYSPROP Database, 2008)) and its preexisting classification for acute toxicity is "Not classified", the substance was classified into "Not classified". |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |